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Background: The endoscopic endonasal approach (EEA) is increasingly used in minimally invasive surgeries for skull base lesions such as pituitary tumors. Although experienced facilities and neurosurgeons familiar with this technique can typically perform these surgeries routinely without special techniques or instruments, challenging cases can occasionally arise due to patient factors such as obesity. Here, we describe challenges encountered during neurosurgery in a patient with super-super obesity and introduce our unique technical nuances for management during tumor resection.
Case Description: We report about a 47-year-old man with a body mass index of 62.24 kg/m who presented for neurosurgery with a diagnosis of craniopharyngioma, for which tumor resection using the EEA under general anesthesia was performed. While planning tumor resection using the EEA, several limitations due to extreme obesity were encountered as follows: (1) management of the respiratory and circulatory systems under general anesthesia, (2) non-feasible positioning on a standard operating table, and (3) complications with lumbar drain (LD) replacement to prevent post-operative cerebrospinal fluid leakage. These challenges were overcome through (1) multidisciplinary collaboration with anesthesiologists and cardiologists, (2) the set-up of two operating tables side by side, and (3) LD placement under awake status in the sitting position, respectively. With these innovations, total tumor resection was achieved using the EEA.
Conclusion: This case highlights the successful use of the EEA along with unique technical adaptations in a super-super obese patient with craniopharyngioma, demonstrating the importance of innovation and problem-solving in overcoming surgical challenges.
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http://dx.doi.org/10.25259/SNI_856_2024 | DOI Listing |
BJS Open
September 2025
Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Background: Appendiceal adenocarcinomas and low-grade appendiceal mucinous neoplasms (LAMNs) are rare tumours. Much of the existing knowledge is derived from registry-based studies, particularly the Surveillance, Epidemiology, and End Results database in the USA.
Methods: This retrospective cohort study used data from the Swedish Cancer Registry, Swedish Cause of Death Registry, and the National Patient Registry to analyse demographic characteristics and outcomes of patients diagnosed with appendiceal adenocarcinoma or LAMN between 2005 and 2019.
ACS Appl Mater Interfaces
September 2025
Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków 30-387, Poland.
The multifunctional systems presented here introduce an innovative and deeply thought-out approach to the more effective and safer use of temozolomide (TMZ) in treating glioma. The developed hydrogel-based flakes were designed to address the issues of local GBL therapy, bacterial neuroinfections, and the bleeding control needed during tumor resection. The materials obtained comprise TMZ and vancomycin (VANC) loaded into cyclodextrin/polymeric capsules and embedded into gelatin/hyaluronic acid/chitosan-based hydrogel films cross-linked with genipin.
View Article and Find Full Text PDFJ Neurooncol
September 2025
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Background And Objectives: Explore whether community social capital measures (system of resources available to individuals through community engagement) are related to surgical outcomes among intracranial tumor patients.
Methods: Adults who underwent resection at a single medical center for intracranial tumor was identified and their zip codes were matched to three variables derived from the Social Capital Atlas: economic connectedness, volunteering rate, and civic organizations. The economic connectedness score quantifies the degree to which low-income and high-income community members are friends with each other, the volunteering rate is defined as the proportion of a given community engaged in community organizations and the civic organization score is defined as the number of local civic organizations within a given community.
J Neurooncol
September 2025
Department of Neurosurgery, Paracelsus Medical University, Breslauer Straße 201, 90471, Nuremberg, Bavaria, Germany.
Purpose: Resection of glioblastomas infiltrating the motor cortex and corticospinal tract (CST) is often linked to increased perioperative morbidity. Navigated transcranial magnetic stimulation (nTMS) motor mapping has been advocated to increase patient safety in these cases. The additional impact of patient frailty on overall outcome after resection of cases with increased risk for postoperative motor deficits as identified with nTMS needs to be investigated.
View Article and Find Full Text PDFNeurosurg Rev
September 2025
Service de Neurochirurgie, GHU-Paris Psychiatrie et Neurosciences, Site Sainte Anne, Paris, F-75014, France.
Awake craniotomy is the gold standard to achieve maximal safe resection of brain lesions located within eloquent areas. There are no established guidelines to assess patient's eligibility for awake craniotomy by weight class. This study assesses feasibility, safety, and efficacy of awake surgery by weight classes through an observational, retrospective, single-institution cohort analysis (2010-2024) of 526 awake craniotomies.
View Article and Find Full Text PDF