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This Special Issue was initiated in response to the call for improved research by the National Academies of Sciences, Engineering, and Medicine (NASEM) (United States) Consensus Study Report on Temporomandibular Disorders (TMDs), a set of putatively localized musculoskeletal conditions. In this Special Issue, the importance of systems biology for TMDs emerges from each of three separate publications. The importance of systems biology to patients is anchored in two domains-laboratory research and clinical observation. The three publications fully speak to the underlying goals in the NASEM recommendations for initiatives: that research on TMDs needs to broaden, that integration between basic and clinical science needs to improve, and that while better evidence is needed, clinicians need to utilize the evidence that already exists. All three of these initiatives, taken together, would lead to better understanding of these complex diseases and to better care of patients with these diseases.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11797808 | PMC |
http://dx.doi.org/10.3389/fdmed.2024.1374883 | DOI Listing |
Oral Surg Oral Med Oral Pathol Oral Radiol
July 2025
Department of Orofacial Pain and TMJ Disorders, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA. Electronic address:
Objective: This systematic review aimed to evaluate and compare the analgesic efficacy of intra-articular morphine versus other agents in managing arthrogenic TMJ disorders.
Study Design: The review adhered to PRISMA guidelines and was registered in PROSPERO (CRD420251011088). A comprehensive search was conducted across PubMed, EMBASE, Scopus, Web of Science, and OVID for randomized controlled trials (RCTs) published up to March 2025.
Oral Dis
September 2025
Graduate Program in Dentistry, Federal University of Pelotas, Pelotas, Brazil.
Objective: This study systematically reviewed the effect of intra-articular injection (IAI) of platelet-rich fibrin (i-PRF), alone or combined with arthrocentesis or arthroscopy, in managing painful articular temporomandibular disorders (TMD) and improving maximum mouth opening (MMO).
Materials And Methods: A systematic literature search was conducted in five databases, identifying randomized and nonrandomized clinical trials focusing on minimally invasive TMJ interventions using i-PRF. Meta-analyses were performed with a random-effects model for studies reporting similar outcomes, visual analog scale (VAS) scores for pain, and MMO values.
J Am Dent Assoc
September 2025
Background: In this narrative review, the authors aimed to provide a focused overview, grounded in scientific literature, of the most common primary and secondary headaches frequently observed in patients with orofacial pain as well as orofacial conditions that may mimic primary headache disorders. In addition, they highlighted the clinically significant overlap between headaches and temporomandibular disorders (TMDs).
Types Of Studies Reviewed: Information was sourced from the International Classification of Headache Disorders, Third Edition, for headache diagnoses and from the International Classification of Orofacial Pain for orofacial pain diagnoses.
J Oral Rehabil
September 2025
Postgraduate School of Orthodontics and Gnathology Unit, Department of Surgical Sciences, Dental School, University of Turin, Turin, Italy.
Background And Objective: Cervical spine impairments are frequent findings among patients with temporomandibular disorders (TMDs). Previous studies have demonstrated that treatments targeting the upper cervical region can improve pain symptoms in patients with TMD. The aim of the current study was to assess whether counselling alone and counselling plus occlusal splint therapy can also provide relief for coexisting neck pain.
View Article and Find Full Text PDFJ Oral Rehabil
September 2025
Health Sciences Department, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Background: Temporomandibular disorders (TMD) is an important source of orofacial pain, which is associated with other symptoms. Due to the chronicity of the condition, self-management strategies are often required. However, little is known about participants' perspectives on the overlapping symptoms and the strategies used to manage facial pain.
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