Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We investigated the phenomenon of pupillary unrest in individuals with Attention Deficit Hyperactivity Disorder (ADHD) compared to neurotypical controls. We measured the power of low-frequency pupil oscillations under two experimental conditions: a passive condition with minimal distraction and a resting condition with no distraction. The study included 76 adult participants (42 controls and 34 with ADHD) aged 18-40. The results show that individuals with ADHD exhibit reduced power in pupillary oscillations, suggesting a suppression of general catecholaminergic activity. The nature of the experiment indicates that this suppression is endemic in the background and independent of the visual task or the ongoing cognitive effort. This finding is consistent with our previous observations of reduced pupil dilations in ADHD during active tasks [1] and provide basic insights for future research aimed at developing and refining a psychophysical paradigm that could serve as a biomarker to enhance ADHD evaluation and classification.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981475 | PMC |
| http://dx.doi.org/10.1016/j.neulet.2025.138148 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of age on PUAL as an indicator of opioid effect in adult subjects.
J Clin Monit Comput
August 2025
Department of Anesthesia and Perioperative Care, University of California San Francisco (UCSF), 94143-0648, San Francisco, California, United States.
Opioid-induced respiratory depression (OIRD) remains a critical safety concern, particularly in older adults, yet timely, reliable detection methods are limited. Decline of pupillary unrest in ambient light (PUAL) has demonstrated potential as a marker of opioid effect in young adult subjects. We evaluated whether previously observed PUAL thresholds for high-risk opioid exposure in younger adults remain valid in 40-60-year-old subjects.
View Article and Find Full Text PDFAEROfen: protocol for a phase I, open-label, randomised crossover study evaluating the efficiency of nebulised fentanyl in healthy volunteers - comparing facial versus intranasal administration via pharmacometric modelling.
BMJ Open
July 2025
Department of Pharmacology, CHU Rouen, Rouen, Haute-Normandie, France.
Introduction: Pain accounts for approximately 80% of emergency department admissions. While intravenous morphine titration is commonly used for severe pain, non-invasive alternatives that bypass intravenous access are needed. Nebulised fentanyl, combined with pupillometry for objective monitoring of opioid impregnation, may offer a rapid and safe alternative for pain management.
View Article and Find Full Text PDFCan the Pupillary Light Reflex and Pupillary Unrest Be Used as Biomarkers of Parkinson's Disease? A Systematic Review and Meta-Analysis.
Diagnostics (Basel)
May 2025
Solvemed Inc., 16192 Coastal Highway, Lewes, DE 19958, USA.
The pathological changes preceding the onset of Parkinson's disease (PD) commence several decades before motor symptoms manifest, offering a potential window for identifying objective biomarkers for early diagnosis and disease monitoring. Among the primary non-motor features of PD is autonomic dysfunction; however, its precise assessment remains challenging, limiting its viability as a reliable biomarker. Both the pupillary light reflex (PLR) and pupillary unrest are regulated by autonomic pathways suggesting their potential as objective non-invasive indicators of the PD prodromal phase.
View Article and Find Full Text PDFCognitive impairment and associated neurobehavioral dysfunction in post-COVID syndrome.
Psychiatry Res
July 2025
Biomagnetic Center, Jena University Hospital, Jena, Germany; Department of Neurology, Jena University Hospital, Jena, Germany. Electronic address:
There is a high prevalence of neuropsychiatric sequelae in post-COVID syndrome, most commonly chronic fatigue, the mechanisms of which remain poorly understood. As altered function of the reward system has been suggested as a causal factor, we aimed to distinguish whether reward processing or task-unspecific cognitive operations are impaired in post-COVID syndrome. Our cohort study included 24 patients diagnosed with post-COVID syndrome and 24 demographically matched healthy controls.
View Article and Find Full Text PDFPupillary unrest is attenuated in attention deficit hyperactivity disorder (ADHD).
Neurosci Lett
March 2025
Think Now, Incorporated, San Francisco, CA, USA.
We investigated the phenomenon of pupillary unrest in individuals with Attention Deficit Hyperactivity Disorder (ADHD) compared to neurotypical controls. We measured the power of low-frequency pupil oscillations under two experimental conditions: a passive condition with minimal distraction and a resting condition with no distraction. The study included 76 adult participants (42 controls and 34 with ADHD) aged 18-40.
View Article and Find Full Text PDF