Transient acantholytic dermatosis induced by nivolumab, successfully treated with dupilumab.

Eur J Dermatol

Section of Dermatology, Dipartimento di Scienze della Salute (DISSAL), Università degli Studi di Genova, Genoa, Italy, Dermatology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Published: December 2024


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http://dx.doi.org/10.1684/ejd.2024.4807DOI Listing

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Grover's disease (GD) is a pruritic skin condition characterized by erythematous, scaly papules on the trunk, often resolving spontaneously but sometimes becoming persistent and difficult to manage. In this case study, we discuss a 73-year-old male with treatment-resistant GD who experienced significant improvement with dupilumab injections. Within two weeks, the patient reported noticeable improvement in pruritus and rash, with complete resolution achieved after five months of continued treatment and no notable adverse effects.

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Transient acantholytic dermatosis induced by nivolumab, successfully treated with dupilumab.

Eur J Dermatol

December 2024

Section of Dermatology, Dipartimento di Scienze della Salute (DISSAL), Università degli Studi di Genova, Genoa, Italy, Dermatology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

View Article and Find Full Text PDF
Article Synopsis
  • * There is a noted but poorly defined connection between GD and cutaneous keratinocyte carcinomas, specifically non-melanoma skin cancers (NMSCs), with very few studies highlighting this relationship between 1983 and 2024.
  • * GD has been misdiagnosed as various NMSCs, and understanding this connection could provide insights into its underlying mechanisms, possibly reclassifying GD as a unique syndrome.
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