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Purpose: To study the prevalence of occult macular pathology using optical coherence tomography (OCT) during the preoperative evaluation for cataract surgery and associated risk factors.
Methods: A retrospective analysis of patients' medical records and imaging. Adult patients who underwent cataract extraction who had normal preoperative fundoscopic examination and available preoperative OCT imaging were included.
Results: The analysis included 121 eyes belonging to 121 patients. The prevalence of occult macular pathology was 21.5%, with the most common being interface abnormalities (8.3% of the eyes), drusen (4.1%), and diabetic macular edema (4.1%). Visually significant pathologies were noted in 6.6% of the eyes. Occult macular pathology was rare in patients aged less than 50 years (4.5%) and common among patients 70 years of age or older (43.3%). The most significant predictors of occult macular pathology were advanced age (OR: 1.06, p = 0.033) and diabetes mellitus (OR: 6.79, p = 0.002).
Conclusion: Relying on fundoscopic evaluation alone would miss 1 in 5 eyes with occult macular pathology and 1 in 15 with pathologies that would alter the visual outcome. Preoperative OCT screening prior to cataract surgery should be considered, especially in patients with advanced age and diabetes mellitus.
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http://dx.doi.org/10.2147/OPTH.S507995 | DOI Listing |
Adv Exp Med Biol
July 2025
Department of Ophthalmology, Sidney Kimmel Medical College at Thomas Jefferson University, New York, NY, USA.
Noninfectious uveitis syndromes are a heterogeneous group of disorders affecting the retina and choroid. Their etiology is unknown, but some follow a flu-like illness. Autoimmune pathogenesis has also been postulated.
View Article and Find Full Text PDFAdv Exp Med Biol
July 2025
Department of Ophthalmology, Columbia University, New York, NY, USA.
Occult macular dystrophy (OMD), also known as Miyake disease, is a rare, autosomal dominant disease. Symptom onset is variable; the majority of patients present in their late twenties with a progressive bilateral decline of central vision, photophobia, and central scotoma. The mean visual acuity is 20/80 but can vary from 20/30 to 20/200 or worse.
View Article and Find Full Text PDFBiomedicines
June 2025
Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Adaptive optics transscleral flood illumination (AO-TFI) enables in vivo, non-invasive, high-resolution imaging of retinal pigment epithelium (RPE) and photoreceptor (PR) cells, paving the way for a new potential characterization of retinal diseases. This study aimed to analyze RPE and PR cells in a case of acute zonal occult outer retinopathy (AZOOR) using AO-TFI. A patient affected by AZOOR underwent a comprehensive eye examination, perimetry, electroretinography (ERG), autofluorescence, and optical coherence tomography (OCT) during the acute phase (T0).
View Article and Find Full Text PDFJ Ophthalmic Inflamm Infect
July 2025
Eye Clinic Sulzbach, Knappschaft Kliniken Saar GmbH, An der Klinik 10, Sulzbach, D-66280, Germany.
Purpose: Acute zonal occult outer retinopathy (AZOOR) is a rare inflammatory disease of the outer retina, often presented with subtle early findings. A specific subtype, termed Multizonal Outer Retinopathy and Retinal Pigment Epitheliopathy (MORR), is characterized by distinct progression pattern (Ramtohul et al. Retina 43:1890–1903, 2023) in multiple zones of the outer retina and retinal pigment epithelium.
View Article and Find Full Text PDFAm J Ophthalmol Case Rep
September 2025
University of Connecticut School of Medicine, Farmington, CT, USA.
Purpose: To describe a rare case of anemic retinopathy as the initial presenting symptom of a mediastinal germ cell tumor.
Observations: A 27-year-old male with no prior medical history presented with a one-day history of central vision loss in his left eye. Funduscopic evaluation showed a central macular hemorrhage in the left eye and bilateral nerve fiber layer hemorrhages and blot hemorrhages.