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Objective: To assess the prevalence of recommended design elements in implemented electronic health record (EHR) interruptive alerts across pediatric care settings.
Materials And Methods: We conducted a 3-phase mixed-methods cross-sectional study. Phase 1 involved developing a codebook for alert content classification. Phase 2 identified the most frequently interruptive alerts at participating sites. Phase 3 applied the codebook to classify alerts. Inter-rater reliability (IRR) for the codebook and descriptive statistics for alert design contents were reported.
Results: We classified alert content on design elements such as the rationale for the alert's appearance, the hazard of ignoring it, directive versus informational content, administrative purpose, and whether it aligned with one of the Institute of Medicine's (IOM) domains of healthcare quality. Most design elements achieved an IRR above 0.7, with the exceptions for identifying directive content outside of an alert (IRR 0.58) and whether an alert was for administrative purposes only (IRR 0.36). IRR was poor for all IOM domains except equity. Institutions varied widely in the number of unique alerts and their designs. 78% of alerts stated their purpose, over half were directive, and 13% were informational. Only 2%-20% of alerts explained the consequences of inaction.
Discussion: This study raises important questions about the optimal balance of alert functions and desirable features of alert representation.
Conclusion: Our study provides the first multi-center analysis of EHR alert design elements in pediatric care settings, revealing substantial variation in content and design. These findings underline the need for future research to experimentally explore EHR alert design best practices to improve efficiency and effectiveness.
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http://dx.doi.org/10.1093/jamia/ocaf013 | DOI Listing |
Endocr Connect
September 2025
Centre for Higher Education Development, University of Cape Town.
Background: Cortisol and growth hormone are important for sleep regulation and cognition. Sleep is critical for cognitive functioning, and memory consolidation. Patients with pituitary disease experience hormonal dysregulation, impaired sleep quality, and cognitive dysfunction.
View Article and Find Full Text PDFJ Exp Anal Behav
September 2025
Endicott College, Beverly, MA, USA.
Decreasing funding for nonhuman animal research decreases the opportunity for students and researchers to explore the behavior of many species in many contexts. In the long run, this will reduce variability within the experimental analysis of behavior around what species are being researched and what questions are being asked. New technologies, however, offer students and researchers the opportunity to observe the behavior of organisms in everyday environments in cost-effective ways.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
School of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Importance: The cost-effectiveness of adding early in-bed cycling to usual physiotherapy among adults receiving mechanical ventilation in the intensive care unit (ICU) compared with usual physiotherapy alone is unknown.
Objective: To evaluate the cost-effectiveness of in-bed cycling plus usual physiotherapy compared with usual therapy alone in the Critical Care Cycling to Improve Lower Extremity Strength (CYCLE) randomized clinical trial.
Design, Setting, And Participants: This trial-based economic evaluation with a 90-day time horizon compared early cycling plus usual physiotherapy vs usual physiotherapy alone from a societal perspective.
Anal Methods
September 2025
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Avapritinib (Ayvakit™) is a highly selective inhibitor of the platelet-derived growth factor receptor alpha (PDGFRA), including D842V mutations. Avapritinib (APB) is authorized in the United States for individuals with metastatic or unresectable gastrointestinal stromal tumors (GISTs). APB is considered the exclusive therapy for adults with indolent systemic mastocytosis.
View Article and Find Full Text PDFJ Infus Nurs
September 2025
Author Affiliations: School of Nursing, Capital Medical University, Beijing, China.
Background: Peripherally inserted central catheter-related thrombosis (PICC-CRT) is a major complication in patients undergoing PICC placement. While a dedicated PICC-CRT prevention system could improve early risk assessment and targeted intervention, nurses' specific needs for such a system remain underexplored. This study aimed to explore specialist registered nurses' perspectives on a PICC-CRT prevention management system.
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