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Context: Understanding how prognosis influences acute care use among older adults at risk of short-term mortality is essential for providing care consistent with patients' wishes.
Objectives: This study assesses whether prognosis is associated with acute care and Intensive Care Unit (ICU) transfer in older adults presenting to the Emergency Department (ED) at high and low risk of short-term mortality.
Methods: For this cross-sectional analysis, we pooled the Medicare claims for older adults 66 years and older from 2015 to 2019 who visited at least one of the 29 EDs participating in the Primary Palliative Care for Emergency Medicine study. Our outcome measures were defined as an acute care admission and ICU transfer resulting from an ED visit, both measured as binary variables. The predictor variables were age, sex, race/ethnicity, and Gagne score. We stratified the analysis into those with low (≤6) and high risk (>6) short-term mortality using the Gagne scores. To assess the odds of an acute care or ICU transfer, we used multivariable logistic regression via generalized estimating equation models and computed the adjusted odds ratios (AOR) among the general population and among those at high risk of short-term mortality.
Results: Of the 301,083 older adults who visited one of the 29 EDs, 13% were at high risk for short-term mortality. Among this high-risk group, 64% had an acute care admission, and 15% of those admitted had an ICU transfer, as compared to 43% and 12% of those at low risk of short-term mortality. Among those at high risk for short-term mortality, prognosis was associated with 6% (AOR 1.06; 95% CI, 1.04-1.09) and 8% (AOR 1.08; 95% CI, 1.06-1.09) increased adjusted odds of inpatient admission and ICU transfer, respectively.
Conclusion: The prognosis of older adults, especially those at high risk of short-term mortality, predicts both inpatient admissions and ICU transfers.
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http://dx.doi.org/10.1016/j.jpainsymman.2025.01.006 | DOI Listing |
J Hazard Mater
September 2025
Chemometrics and Molecular Modeling Laboratory, Department of Chemistry and Physics, Kean University,1000 Morris Avenue, Union, NJ 07083, USA. Electronic address:
The Toxic Substances Control Act (TSCA) mandates the U.S. EPA to monitor all chemicals used in the country, over 86,000 to date, posing a major challenge for comprehensive toxicity testing.
View Article and Find Full Text PDFJ Public Health (Oxf)
September 2025
Institute of Sociology, University of Neuchâtel, 2000 Neuchâtel, Switzerland.
Background: This article examined to what extent pandemic-related exposures were associated with negative affect up to 2.5 years from the outbreak of the pandemic in Switzerland.
Methods: We drew on longitudinal data from five waves (2018-22) of the Swiss Household Panel, including the pandemic questionnaire collected in May-June 2020 (n = 5657).
Farm Hosp
September 2025
Servicio de Farmacia, Hospital Universitario de Toledo, Toledo, Spain.
Objective: To standardize the drug dilutions administered intravenously in a Pediatric Intensive Care Unit and to characterize these dilutions based on their pH, osmolarity, and vesicant nature. This aims to guide the selection of the most appropriate vascular access device, minimizing associated complications, and preserving the patient's venous capital.
Methods: Through a consensus between Pharmacy and Pediatric Services, the most frequently administered intravenous drugs in the Pediatric Intensive Care Unit were selected.
J Nutr
September 2025
School of Medicine and Allied Health Sciences, University of The Gambia, Banjul, The Gambia; Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, Shandong 250
Background: Red and processed meat consumption is extensively linked to chronic disease risk in observational studies, with robust meta-analyses demonstrating significant positive associations for colorectal, breast, endometrial, and lung cancers, type 2 diabetes (T2DM), cardiovascular disease (CVD), and all-cause mortality. Dose-response relationships indicate elevated risks even at moderate intakes. Moreover, processed meats consistently show stronger detrimental effects than unprocessed red meats.
View Article and Find Full Text PDFAm J Med Sci
September 2025
The George Washington University School of Medicine and Health Sciences, Washington, DC.
Background: In transcatheter aortic valve replacement (TAVR), there is a notable "diabetes discrepancy", where worse/better/similar outcomes were all found for patients with diabetes mellitus (DM). Such divergent findings pose a challenge for clinicians to accurately assess the risks for DM patients undergoing TAVR. We hypothesized the presence of chronic complications could be linked to worse post-TAVR outcomes in DM patients.
View Article and Find Full Text PDF