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Valvular heart disease (VHD) leading to inadequate hemodynamic circulation is a major cause of cardiovascular morbidity and mortality worldwide. Right ventricular-pulmonary artery (RV-PA) coupling integrates the ability of RV contractility to adapt to increased pulmonary arterial afterload. If the right ventricle cannot adapt to the elevated afterload by increasing its contractile function, RV-PA uncoupling occurs. RV-PA uncoupling has been shown to be associated with poor outcomes in VHD. This review summarizes the prognostic significance of RV-PA coupling in patients with VHD.
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http://dx.doi.org/10.3389/fcvm.2024.1504063 | DOI Listing |
Diagnostics (Basel)
August 2025
Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Heart failure (HF) imposes a significant burden on public health, affecting over 56.19 million people worldwide. Right ventricular (RV) dysfunction may occur in HF patients due to various factors, including adverse interventricular interactions, ischemic heart disease, and HF-correlated pulmonary hypertension.
View Article and Find Full Text PDFIndian J Thorac Cardiovasc Surg
September 2025
Department of Cardiac Surgery, Rabindranath Tagore International Institute of Cardiac Sciences, Narayana Health, Kolkata, India.
This review revisits the 5-year echocardiographic findings from the PARTNER 3 trial, which assessed valve performance in low-surgical-risk patients undergoing transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR). While TAVR demonstrated early hemodynamic advantages, including more favourable right ventricular-pulmonary artery coupling and lower valvulo-arterial impedance, these benefits did not consistently translate into superior long-term outcomes. Emerging data from companion publications highlight a potential late mortality in the TAVR group, despite comparable early results.
View Article and Find Full Text PDFAnn Pediatr Cardiol
July 2025
Division of Interventional Cardiology, Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia.
Background: Pulmonary arterial hypertension (PAH) is a chronic, progressive disease affecting the pulmonary vasculature, with a high mortality rate. Patients with PAH due to congenital heart disease (CHD) (World Health Organization Group 1) exhibit significantly reduced exercise tolerance compared to other PAH groups. Right ventricular (RV) dysfunction is a commonly used independent prognostic parameter in PAH.
View Article and Find Full Text PDFJ Am Heart Assoc
August 2025
Department of Respiratory Medicine, Faculty of Medicine Hokkaido University Sapporo Japan.
Background: Limited data exist on right ventricular (RV) function in lung disease/hypoxia-associated pulmonary hypertension (PH). We aimed to clarify the presence, characteristics, and clinical significance of RV dysfunction in patients with lung disease/hypoxia-associated PH.
Methods: We analyzed data from 3 groups of patients: those with lung disease/hypoxia-associated PH, those without PH, and those with pulmonary arterial hypertension (PAH).
Int J Cardiol Congenit Heart Dis
September 2025
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
Background: Right ventricular (RV) systolic dysfunction and pulmonary hypertension is present in 20 % of adults with repaired coarctation of aorta (COA). However, the prognostic value of RV to pulmonary artery (RV-PA) coupling in this population is unknown. The purpose of this study was to assess the relationship between RV-PA coupling and clinical outcomes (heart failure hospitalization and all-cause mortality) in this population.
View Article and Find Full Text PDF