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Aim: Accurate and appropriate cognitive screening can significantly enhance early psychosis care, yet no screening tools have been validated for the early psychosis population and little is known about current screening practices, experiences, or factors that may influence implementation. CogScreen is a hybrid type 1 study aiming to validate two promising screening tools with young people with first episode psychosis (primary aim) and to understand the context for implementing cognitive screening in early psychosis settings (secondary aim). This protocol outlines the implementation study, which aims to explore the current practices, acceptability, feasibility and determinants of cognitive screening in early psychosis settings from the perspective of key stakeholders.
Methods: Young people with first episode psychosis (n = 350), caregivers (minimum n = 10) and service providers (minimum n = 12) will be recruited from primary and specialist early psychosis services in Melbourne, Adelaide and Sydney, Australia. Two implementation science frameworks will inform data collection and analysis: the Theoretical Framework of Acceptability and the Consolidated Framework for Implementation Research. A mixed-methods design will be employed to collect and analyse data from questionnaires with young people, interviews with all stakeholder groups, and administrative processes. Quantitative data will be analysed using descriptive statistics. Qualitative data will be analysed through content analysis using deductive and inductive coding.
Results And Discussion: This protocol paper presents the rationale and methods for the CogScreen implementation study.
Conclusion: Together with accuracy findings, results from the implementation study will provide insights about the practices, experiences, enablers and barriers to cognitive screening in early psychosis services.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771705 | PMC |
http://dx.doi.org/10.1111/eip.70004 | DOI Listing |
Eur Child Adolesc Psychiatry
September 2025
Mental Health Unit, Virgen del Rocio University Hospital, Seville, Spain.
The COVID-19 pandemic brought unprecedented global challenges. Amid the crisis, the potential impact of COVID-19 exposure on the neurodevelopment of offspring born to infected mothers emerged as a critical concern. This is a prospective cohort study of pregnant women and their offspring enrolled in the Signature project at Hospital Universitario Virgen del Rocio in Seville, Spain, between 01/01/2024 and 08/31/2022.
View Article and Find Full Text PDFBackground: Schizotypy (ST) and psychotic-like experiences and negative symptoms (PENS) are commonly used phenotypes in high-risk and early intervention research for schizophrenia and other non-affective psychoses. However, the origin of these phenotypes in the general population is poorly understood and their association with the genetic predisposition to psychoses has not yet been proven.
Aim: The aim of this study is to answer the question of whether data on the relations of ST and PENS with polygenic risk scores for schizophrenia (SZ-PRS) support the hypothesis that these phenotypes are subclinical manifestations of genetic liability for schizophrenia.
Behav Cogn Psychother
September 2025
Early Intervention in Psychosis Services, Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.
Background: Hallucinations and other unusual sensory experiences (USE) are common in people with psychosis. Yet access to effective psychological therapies remains limited. We evaluated if we can increase access to psychological therapy by using a brief treatment, focused only on understanding and dealing with hallucinations (Managing Unusual Sensory Experiences; MUSE), delivered by a less trained but more widely available workforce that harnessed the benefits (engaging content, standardisation) afforded by digital technology.
View Article and Find Full Text PDFNat Aging
September 2025
Aging Biomarker Consortium (ABC), Beijing, China.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.
View Article and Find Full Text PDFJ Psychiatr Res
September 2025
Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, 300222, China. Electronic address:
Background: The duration of untreated psychosis (DUP) is a critical factor influencing long-term outcome in schizophrenia (SCZ). Its short-term effects during early treatment remain less well characterized.
Methods: We enrolled 300 drug-naïve SCZ patients, of whom 78 completed a 12-week evaluation with comprehensive clinical and functional assessments.