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Tuberculosis is no longer confined to developing nations; it persists as a significant contributor to illness and death on a global scale. The subtle clinical manifestation and association with human immunodeficiency virus infection poses obstacles for early diagnosis and management. Tuberculosis manifesting at extrapulmonary sites is relatively rare. We herein present the case of a 26-year-old patient from Cameroon with a history of pleuropulmonary tuberculosis treated in 2008, who had been taking pre-exposure prophylaxis (PrEP). The patient presented with right shoulder pain of an inflammatory type. The case was diagnosed as tuberculous osteomyelitis of the scapular spine, complicated by a deltoid abscess. Diagnosis was confirmed using computed tomography and the MTB/RIF GeneXpert test on the abscess puncture. This rare form of tuberculosis with an exceptional site revealed a HIV infection with profound immunosuppression. The patient was initiated on anti-tubercular treatment according to Moroccan recommendations.
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http://dx.doi.org/10.3390/tropicalmed10010008 | DOI Listing |
Cureus
August 2025
Orthopaedics, Mahatma Gandhi Medical College and Research Institute, Pondicherry, IND.
Tuberculous osteomyelitis of the proximal tibia is an extremely rare condition in pediatric patients, often presenting as chronic pain, swelling, and nonspecific symptoms that mimic pyogenic osteomyelitis or bone tumors. We report the case of a three-year-old boy who presented with localized swelling and pain in the right proximal tibia for the past 1.5 months.
View Article and Find Full Text PDFBMC Musculoskelet Disord
September 2025
Departments of Orthopedics, Hangzhou Ninth People's Hospital, Hangzhou, Zhejiang, 310000, China.
Background: The burden of spinal tuberculosis (STB) in China remains substantial, with the country ranking third in the number of tuberculosis cases globally in 2022, among the 30 countries with a high tuberculosis burden. In East China, few large-scale studies have been conducted on STB.
Methods: This retrospective study analyzed 893 confirmed STB cases (2010-2020).
J Orthop Surg Res
August 2025
Department of Orthopedic, General Hospital of Ningxia Medical University, Ningxia Hui Autonomous Region, No.804 Shengli Street, Yinchuan, 750004, China.
Background: N6-methyladenosine (m6A) is the most common and abundant internal modification in RNA. However, the role of m6A in spinal tuberculosis (STB) remains incompletely elucidated. In our previous study, miRNA-seq was performed on peripheral blood and tissues from STB patients, and miR-29a-3p was identified as differentially expressed in STB patients through screening.
View Article and Find Full Text PDFAnn Ital Chir
August 2025
Department of Emergency, Yongchuan Hospital of Chongqing Medical University, 402160 Chongqing, China.
Aim: Lumbar tuberculosis can cause spinal instability and neurological deficits, often requiring surgery. Traditional anterior-posterior surgery is effective but highly invasive, leading to greater trauma and longer recovery. Minimally invasive techniques, such as oblique lumbar debridement with posterior percutaneous fixation, may reduce surgical damage and improve recovery.
View Article and Find Full Text PDFJ Orthop Surg Res
August 2025
Public Health Clinical Affiliated to Shandong University, Jinan City, Shandong Province, China.
Background: Surgical treatment of thoracic spine tuberculosis using traditional procedures is often challenged by high trauma and slow recovery. This study aimed to investigate the short- and medium-term efficacy and safety of Uniportal Video-Assisted Thoracoscopic Surgery, a minimally invasive single-port thoracoscopy combined with posterior internal fixation for the treatment of thoracic spinal tuberculosis.
Methods: Nineteen patients with thoracic spinal tuberculosis (15 men and four women, mean age of 52 years) were retrospectively included.