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| http://dx.doi.org/10.1016/j.diii.2025.01.001 | DOI Listing |
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Relationship between global limb anatomic staging system (GLASS) and short- and mid-term endovascular treatment outcomes in chronic limb-threatening ischemia (CLTI) patients with infra-inguinal lesions.
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Department of Vascular and Endovascular Surgery, Assiut University Hospitals, Assiut, Egypt.
BackgroundChronic limb-threatening ischemia (CLTI), a severe form of peripheral artery disease (PAD), results in significant morbidity and mortality. The Global Limb Anatomic Staging System (GLASS) is a new tool designed to predict outcomes in CLTI patients undergoing endovascular treatments, yet its relationship with short-term outcomes requires further investigation.ObjectiveThis study evaluates the correlation between GLASS staging and short-term outcomes in CLTI patients treated with endovascular procedures for infrainguinal lesions.
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Department of Radiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, China.
Neonatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of developmental disorders and permanent central nervous system damage, with functional recovery closely linked to myelin sheath integrity. This study aimed to analyze the expression of pH and the voltage-gated proton channel (Hv1) in the brains of neonatal pigs with HIE at various time points, alongside changes in myelin-related proteins. MRI was employed to localize the basal ganglia and assess pH changes post-hypoxia-ischemia, while immunofluorescence staining was used to evaluate Hv1, myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and myelin-associated glycoprotein (MAG).
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Department of Neuroscience, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Brain ischemia is a major global cause of disability, frequently leading to psychoneurological issues. This study investigates the effects of 4-aminopyridine (4-AP) on anxiety, cognitive impairment, and potential underlying mechanisms in a mouse model of medial prefrontal cortex (mPFC) ischemia. Mice with mPFC ischemia were treated with normal saline (NS) or different doses of 4-AP (250, 500, and 1000 µg/kg) for 14 consecutive days.
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Department of Urology/School of Clinical Medicine, North Sichuan Medical College/Affiliated Hospital of North Sichuan Medical College, No. 1, South Maoyuan Road, Shunqing District, Nanchong City, 63700, Sichuan Province, China.
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