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Cluster headache is a severe primary headache disorder, which can be associated with a substantial impairment for sufferers. The Cluster Headache Impact Questionnaire (CHIQ) is a short questionnaire for measuring the cluster headache-specific impairment. A 5-stage severity grading from "no to low impairment" to "'extreme impairment" was established based on the results of an English-speaking patient collective. The present article tested whether the severity classification can be transferred to a German patient group. Data from 196 patients with episodic and chronic cluster headache were examined during an active episode. The severity grading classification of the CHIQ also showed clinically relevant results in the German collective, i.e., the five degrees of severity showed significant differences with respect to attack frequency, intake of acute medication and unspecific headache-related impairment (HIT-6) and quality of life (SF-12v2). Interestingly, 32 out of 52 patients with episodic cluster headache outside the active epísode suffered an impairment above the lowest severity grade, i.e., at least a moderate impairment. In conclusion, the CHIQ provides a short instrument to document the current impairment in cluster headache patients. The severity grading classification presented here facilitates the clinical interpretation.
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http://dx.doi.org/10.1007/s00482-024-00859-1 | DOI Listing |
Expert Rev Neurother
September 2025
Department of Neurology, Tallaght University Hospital (TUH)/The Adelaide and Meath Hospital incorporating the National Children's Hospital (AMNCH), Dublin, Ireland.
Introduction: Refractory migraine (RM) is characterized by a lack of response to both migraine-specific and repurposed treatments, significantly impairing quality of life. Risk factors for RM include, among others, overuse of symptomatic medications, nonadherence to treatment and comorbid conditions that limit the use of anti-migraine medications.
Areas Covered: This critical perspective addresses the diagnosis and management of patients with RM.
J Addict Dis
September 2025
Department of Psychiatry and Behavioral Health, Ohio State University Wexner Medical Center Talbot Hall, Columbus, OH, USA.
Background: Comorbidity between opioid use disorder (OUD) and chronic pain is substantial. Pain has been shown to be a motivator for OUD onset, maintenance, relapse, and treatment delay. A cluster of pain conditions known as chronic overlapping pain conditions (COPCs), also now referred to in contemporary ICD classification as primary pain conditions, are particularly refractory to traditional forms of pain treatment, and likely adversely impact comorbid OUD.
View Article and Find Full Text PDFCephalalgia
September 2025
NIHR King's Clinical Research Facility and SLaM Biomedical Research Centre, King's College, London, UK.
AimTo evaluate the effectiveness and tolerability of non-invasive vagus nerve stimulation (nVNS) as acute or preventive treatment, or both, in a cohort of trigeminal autonomic cephalalgia (TAC) patients.MethodsA service evaluation retrospectively included patients with TACs between January 2014 and February 2025 who had used, or currently use, nVNS. Data were collected from clinical letters.
View Article and Find Full Text PDFACR Open Rheumatol
September 2025
Rheumatology, Department of Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
Objective: To explore the cerebrospinal fluid (CSF) proteome in systemic lupus erythematosus (SLE) and the associations between the CSF proteomic patterns and clinical manifestations.
Methods: CSF samples from 29 female outpatients with SLE were analyzed with label-free liquid chromatography tandem mass spectrometry. Inclusion and CSF collection were conducted irrespective of clinical manifestations and disease duration.
Life (Basel)
July 2025
Juvenile Headache Center, Department of Woman's and Child's Health, University of Padua, 35128 Padua, Italy.
Many headaches at night arise due to primary headache disorders, which occur independently of other symptoms and are not caused by another medical condition. Primary headache disorders with nighttime attacks can include tension-type headaches, migraines, hypnic headaches, and cluster headaches. A hypnic headache is sometimes called an "alarm clock headache" because symptoms tend to arise at the same time of night.
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