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http://dx.doi.org/10.1016/j.ymthe.2025.01.001 | DOI Listing |
Vaccine
August 2025
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:
Significant challenges are presented as a result of the ongoing HIV/AIDS pandemic, particularly given the ongoing burden of new infections and the lack of a proven treatment. Among other approaches, vaccinations based on Dendritic Cells (DCs) have become a viable tactic in the fight against HIV. These vaccines take advantage of DCs' special capacity to deliver antigens, which makes them crucial mediators between innate and adaptive immune responses.
View Article and Find Full Text PDFMol Ther
February 2025
Department of Microbiology and Immunology, Western University, London, ON N6A 3K7, Canada. Electronic address:
ACS Appl Bio Mater
January 2025
Department of Chemistry, Shiv Nadar Institution of Eminence, Delhi-NCR, Uttar Pradesh 201314, India.
Bacterial infections impede wound healing and pose significant challenges in clinical care. There is an immediate need for safe and targeted antivirulence agents to fight bacterial infections effectively. In this regard, bioderived nanovesicles have shown significant promise.
View Article and Find Full Text PDFCancer Rep (Hoboken)
May 2024
Laboratory of Chromatin Biology & Epigenetics, Indian Institute of Science Education and Research, Pune, India.
Background: Statins, frequently prescribed medications, work by inhibiting the rate-limiting enzyme HMG-CoA reductase (HMGCR) in the mevalonate pathway to reduce cholesterol levels. Due to their multifaceted benefits, statins are being adapted for use as cost-efficient, safe and effective anti-cancer treatments. Several studies have shown that specific types of cancer are responsive to statin medications since they rely on the mevalonate pathway for their growth and survival.
View Article and Find Full Text PDFComput Biol Med
July 2022
Department of Chemistry, Shiv Nadar University, Greater Noida, 201314, India.
Tuberculosis (TB) is a serious communicative disease caused by Mycobacterium tuberculosis. Although there are vaccines and drugs available to treat the disease, they are not efficient, moreover, multidrug-resistant TB (MDR-TB) become a major hurdle in its therapy. These MDR strains utilize the multidrug efflux pump as a decisive weapon to fight against antitubercular drugs.
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