Ex Situ Generation of D for Reductive Deuteration: Scope and Application to Late-Stage Functionalization.

An efficient deuteration method through the ex situ generation of D for the reductive deuteration of biologically significant α-substituted acrylic acids and enamide derivatives is reported. This method was successfully applied to the synthesis of deuterated analogs of marketed NSAIDs such as ibuprofen, flurbiprofen, and naproxen. Additionally, it facilitates late-stage deuteration of enamides and -vinylated drugs. Moreover, the method was extended to -viny azoles, cinnamic acid derivatives, and other unsaturated substrates toward deuteration reaction. This technique utilizes DO as a safe and economical deuterium source. Notably, the reaction is performed in a standard fume hood setup, ensuring ease of handling and enhanced practicality.