Selective Synthesis of Amines by Heterogeneous Co Catalysts via Borrowing Hydrogen Protocols.

Org Lett

Laboratory for Materials and Structures, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.

Published: January 2025


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Article Abstract

Developed Co-MgO/TiO was applicable to C-N bond formation by direct amination of primary and secondary alcohols with NH via a borrowing hydrogen protocol. Selective synthesis of primary, secondary, and tertiary amines was achieved by controlling the reaction conditions. Asymmetric secondary amines can be synthesized by the coupling of alcohols and amines.

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http://dx.doi.org/10.1021/acs.orglett.4c04633DOI Listing

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