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In this work, the characterization and diversity of 347 compounds from betel nut ( L.) were analyzed for the first time. The dataset of compounds from betel nut (BNC) was compared to compounds from food. They were analyzed in terms of physicochemical properties, scaffold diversity, molecular fingerprints, and global diversity. Approximately 48% of compounds in the BNC confirm Lipinski's and Pfizer's rules. The pharmacological and toxicological properties of edible betel nut were evaluated based on their composition. This work applied the research methods of cheminformatics to food science, and it provided theoretical support and data for betel nut pharmacological research, development of betel nut-related novel medication, and healthy products.
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http://dx.doi.org/10.1021/acsomega.4c09386 | DOI Listing |
Subst Use Misuse
September 2025
Population Sciences in the Pacific Program, University of Hawai'i Cancer Center, Honolulu, HI, USA.
: While there are known high rates of tobacco and betel (areca) nut use in the U.S.-Affiliated Pacific Islands (USAPI), there have been limited efforts at preventing the initiation of tobacco and betel nut among those living in the region, particularly, adolescents.
View Article and Find Full Text PDFJ Oral Pathol Med
September 2025
Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Arabian Gulf University, Manama, Bahrain.
Background: Smokeless tobacco (SLT) use is a major global risk factor for oral potentially malignant disorders (OPMDs). However, the differential impact of SLT product composition, particularly tobacco-only versus combined tobacco-areca nut products, on OPMD prevalence remains inadequately characterized.
Objective: To compare the pooled prevalence of OPMDs between users of tobacco-only SLT and users of SLT containing both tobacco and areca nut.
Chem Biol Interact
August 2025
Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China; Department of Oral Medicine, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China; Institute of Oral Precancerous Lesions, Central South Uni
Oral submucous fibrosis (OSF) is a chronic fibrotic disease common in Asia-Pacific regions and strongly linked to long-term areca nut chewing. Fibroblast senescence is known to contribute to tissue fibrosis, but the molecular mechanisms behind it remain unclear. In this study, we explored how arecoline, a key component of areca nut, influences fibroblast behavior.
View Article and Find Full Text PDFDent J (Basel)
August 2025
College of Dentistry, University of Saskatchewan, 105 Wiggins Road, Saskatoon, SK S7N 5E4, Canada.
The areca nut (AN) is chewed by approximately 600 million people worldwide. Among AN chewers, ~5% develop oral submucosal fibrosis (OSF), a progressive fibrotic disorder of the oral cavity. OSF is characterized by subepithelial fibrosis and mucosal rigidity, leading to restricted mouth opening, difficulty in mastication, deglutition, and speech.
View Article and Find Full Text PDFInd Psychiatry J
July 2025
Consultant in Medicine at MMFHA Joshi Hospital, Pune, Maharashtra, India.
Background: Tobacco use is the largest preventable risk of non-communicable diseases (NCDs). Moreover, tobacco use interferes with glycaemic control, and there is a proven link between smoking and diabetes complications.
Aim: This cross-sectional study investigates the prevalence of tobacco use and the effect of advice about quitting and its impact at one-month and one-year follow-ups in outpatient type 2 diabetics.