Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Mechanical thrombectomy (MT) for medium vessel occlusions (MeVO) is emerging as a promising treatment in acute stroke. We aim to evaluate the utility of additional imaging (CTP) in patients with MeVOs who received thrombolysis at a spoke hospital and were transferred to the hub.
Methods: This was a retrospective review of prospectively collected data from April 2018 to June 2023. Patients were transferred to one of the following destinations: CT scanner for a perfusion scan, directly to the angiography suite, or admitted to the neurological intensive care unit (NICU). We compared baseline characteristics, MT times, radiographic and clinical outcomes between the group that was initially transferred to CTP vs. the group that was not initially transferred to CTP.
Results: Seventy-eight MeVO patients who received IV thrombolysis and were transferred to our comprehensive stroke center were included in the analysis. Forty patients went directly to CTP, thirty went directly to the angiography suite (DTA), and eight were transferred to the NICU. 67.5% of patients presenting to CTP did not subsequently go to the angiography suite. The CTP and non-CTP groups did not differ significantly in terms of demographics, rates of successful recanalization, complications, and clinical outcomes at 90 days. The CTP group had significantly longer median door-to-groin times and median door-to-recanalization times.
Conclusion: Mechanical thrombectomy should be considered in stroke patients with confirmed medium vessel occlusions who receive thrombolysis. CTP utilization may lead to lower angiography utilization and longer door-to-procedure times but does not significantly affect long-term outcomes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748375 | PMC |
| http://dx.doi.org/10.1177/15910199251313571 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rapidly Progressive Primary Central Nervous System Vasculitis: A Rare Case with Multifocal Small and Medium Vessel Involvement.
Eur J Case Rep Intern Med
August 2025
Department of Internal Medicine, Dubai Hospital, Dubai Health, Dubai, Dubai, United Arab Emirates.
Introduction: Primary central nervous system vasculitis (primary CNS vasculitis) is a rare inflammatory disorder that affects small-to-medium-sized cerebral vessels, often leading to recurrent strokes. Diagnosis is vague due to non-specific neurological symptoms. Imaging findings, cerebrospinal fluid (CSF) analysis and exclusion of systemic vasculitis are essential for diagnosis.
View Article and Find Full Text PDFImpact of Serum/Xeno-Free Medium and Cytokine Supplementation on CAR-T Cell Therapy Manufacturing in Stirred Tank Bioreactors.
Biotechnol J
September 2025
Department of Biochemical Engineering, University College London, London, UK.
Chimeric antigen receptor T-cell (CAR-T) therapies have demonstrated clinical efficacy in treating haematological malignancies, resulting in multiple regulatory approvals. However, there is a need for robust manufacturing platforms and the use of GMP-aligned reagents to meet the clinical and commercial demands. This study investigates the impact of serum/xeno-free medium (SXFM) and cytokine supplementation on CAR-T cell production in static and agitated culture systems, using 24-well plate G-Rex vessels and 500 mL stirred tank bioreactors (STRs), respectively.
View Article and Find Full Text PDFFrom Dermatology to Nephrology: Unveiling Granulomatosis With Polyangiitis.
Cureus
August 2025
Internal Medicine, Hospital General Dr. Dario Fernandez Fierro, Mexico City, MEX.
Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, is a rare form of pauci-immune vasculitis that primarily affects the respiratory tract and kidneys, though it can involve virtually any organ system. As a systemic vasculitis, it targets small- and medium-sized blood vessels and is associated with anti-neutrophil cytoplasmic antibodies (ANCA), particularly those directed against proteinase 3 (PR3). Due to its nonspecific symptoms and variable clinical presentation, GPA requires a high index of suspicion for timely diagnosis.
View Article and Find Full Text PDFThrombectomy for medium-sized cerebral vessel occlusion: Size does matter.
Eur Stroke J
September 2025
Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Introduction: Randomised controlled trials comparing endovascular thrombectomy (EVT) to medical treatment in patients with medium vessel occlusion (MeVO) suggested neutrality or futility of EVT. We studied whether the size difference between thrombectomy device and the occluded vessel influenced MeVO outcomes.
Patients And Methods: This was a retrospective single-centre observational study comprising EVT-treated patients with occlusion of the M2 branch of the middle cerebral artery on digital subtraction angiography.
Transcranial ultrasound localization microscopy of the rat brain with ray theory-based aberration correction.
Ultrasonics
August 2025
College of Biomedical Engineering, Fudan University, Shanghai 200438, China; State Key Laboratory of Integrated Chips and Systems, Fudan University, Shanghai 200438, China; Poda Medical Technology Co., Ltd., Shanghai 200433, China. Electronic address:
Transcranial ultrasound localization microscopy (t-ULM) is faced with challenges posed by the skull, including acoustic attenuation and phase aberrations. There is a significant request for an efficient aberration correction method achieving a great balance between computational complexity and accuracy. In this study, the ray theory is first applied to in-vivo transcranial imaging to calculate the traveltime table in the inhomogeneous medium model of the imaging region.
View Article and Find Full Text PDF