98%
921
2 minutes
20
This case report highlights the diagnostic and therapeutic complexities faced by a 56-year-old female with Good's syndrome (GS), who presented with persistent Coronavirus Disease 2019 (COVID-19) infection alongside spp, , and co-infection, which collectively contributed to severe pulmonary involvement. The report further emphasizes a multifaceted treatment approach, incorporating antivirals, antifungals, antimicrobials, immunoglobulins, and antifibrotic therapy, which ultimately led to an improvement in the patient's condition. It underscored the intricate challenges of managing immunocompromised patients with multiple concurrent infections. The detailed diagnosis and treatment process of this complex case provides valuable insights to clinicians managing similar scenarios.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732523 | PMC |
http://dx.doi.org/10.1016/j.heliyon.2024.e41382 | DOI Listing |
Neurol Sci
July 2025
Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Br J Dermatol
July 2025
Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Background: Chronic recalcitrant dermatophyte infection (CRDI) remains poorly understood, with limited research on its genetic, immunological, and treatment aspects.
Objectives: To investigate the genetic and immunological profiles, clinical characteristics, and treatment outcomes in otherwise healthy patients with CRDI.
Methods: A prospective study included patients with isolated superficial dermatophyte infections persisting for over five years and refractory to at least three oral antifungal agents.
Eur J Case Rep Intern Med
June 2025
Internal Medicine Department, Les Cevennes Hospital, Alès, France.
Unlabelled: Thymus is a primary lymphoid organ whose main function is the education of the T lymphocytes. Thymoma is uncommon neoplasia derived from epithelial cells of the thymus. Patients with thymoma frequently present with autoimmune disorders, mostly myasthenia gravis.
View Article and Find Full Text PDFCureus
June 2025
Infectious Diseases, Hospital Sultanah Aminah, Johor Bahru, MYS.
Good's syndrome is a rare immunodeficiency disorder associated with thymoma, characterized primarily by hypogammaglobulinemia and B-cell deficiency. Patients with Good's syndrome exhibit compromised immunity, rendering them highly susceptible to recurrent infections. This report describes the case of a patient who developed multiple episodes of pneumonia and persistent diarrhea following thymomectomy for thymoma, ultimately leading to the diagnosis of Good's syndrome.
View Article and Find Full Text PDFZhonghua Nei Ke Za Zhi
July 2025
Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
We herein report a case of recurrent coronavirus disease 2019 (COVID-19) in a 56-year-old female with Good's syndrome (GS) at Peking Union Medical College Hospital in April 2024. The patient was previously treated with thymectomy for thymoma and her immunoglobulin assays and lymphocyte subset analysis confirmed an immunocompromised state characterized predominantly by humoral immunodeficiency, consistent with a diagnosis of GS. Clinical symptoms improved following two courses of nirmatrelvir/ritonavir and four courses of molnupiravir, administered alongside adjunctive glucocorticoids and regular intravenous immunoglobulin (IVIG) supplementation.
View Article and Find Full Text PDF