Article Synopsis
- MASLD includes a range of liver conditions, from simple fat accumulation to severe inflammation and potential liver damage.
- The study found specific bacteria in liver and fat tissues that correlate with the severity of MASLD, with certain bacteria linked to higher inflammation and immune responses.
- Understanding these microbial patterns can shed light on how gut bacteria contribute to the progression of liver disease and may influence treatment strategies.
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Article Abstract
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a range of histological findings from the generally benign simple steatosis to steatohepatitis (MASH) which can progress to fibrosis and cirrhosis. Several factors, including the microbiome, may contribute to disease progression.
Results: Here, we demonstrate links between the presence and abundance of specific bacteria in the adipose and liver tissues, inflammatory genes, immune cell responses, and disease severity. Overall, in MASLD patients, we observed a generalized obesity-induced translocation of gut bacteria to hepatic and adipose tissues. We identified microbial patterns unique to more severely diseased tissues. Specifically, Enterococcus, Granulicatella, and Morganellaceae abundance is positively correlated with immune cell counts and inflammatory gene expression levels, and both genera are significantly enriched in MASH patients. Brevibacterium is enriched in adipose tissues of patients with liver fibrosis.
Conclusion: Together, these results provide further insight into the microbial factors that may be driving disease severity. Video Abstract.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730849 | PMC |
| http://dx.doi.org/10.1186/s40168-024-02004-7 | DOI Listing |
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