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Colour plays an important role in the sighted world, not only by guiding and warning, but also by helping to make decisions, form opinions, and influence emotional landscape. While not everyone has direct access to this information, even people without colour vision (i.e., blind, achromatope) understand the meanings of colour terms and can assign sensory and affective properties to colours. To learn which aspects of colour are transmitted non-visually, and thus, are pertinent to those without colour vision, we conducted qualitative interviews with 11 participants (2 congenitally blind, 2 early blind, 4 late blind, 2 late blind with synaesthesia, and 1 achromatope). Our thematic analysis revealed that all participants had detailed knowledge of colours and displayed opinions and attitudes. Colour was important to them as it allowed to take part in the sighted world, navigate the surroundings, and communicate with the sighted peers. While participants with non-congenital colour vision absence could remember and even visualise colours, colour was more abstract to participants with congenital colour vision absence. This was possibly a reason why colour was not very important to their personal lives. Nonetheless, all our participants associated colours with diverse objects, concepts, and emotions, and also had colour preferences, indicating that semantic (conceptual, symbolic, affective) meanings of colour can be transmitted without direct visual experience. Future quantitative and qualitative studies are needed for a systematic understanding of such connotations in the visually impaired population, and their implications to those who can and cannot see colour.
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http://dx.doi.org/10.1016/j.actpsy.2024.104682 | DOI Listing |
Neurol Neuroimmunol Neuroinflamm
November 2025
Departments of Neurology and Ophthalmology, NYU Grossman School of Medicine, NY; and.
Background And Objectives: While reductions in optical coherence tomography (OCT) pRNFL and ganglion cell-inner plexiform layer thicknesses have been shown to be associated with brain atrophy in adult-onset MS (AOMS) cohorts, the relationship between OCT and brain MRI measures is less established in pediatric-onset MS (POMS). Our aim was to examine the associations of OCT measures with volumetric MRI in a cohort of patients with POMS to determine whether OCT measures reflect CNS neurodegeneration in this patient population, as is seen in AOMS cohorts.
Methods: This was a cross-sectional study with retrospective ascertainment of patients with POMS evaluated at a single center with expertise in POMS and neuro-ophthalmology.
Medicine (Baltimore)
September 2025
Al Mouwasat University Hospital, Damascus University, Damascus, Syria.
Rationale: Systemic sclerosis (SS) is an immune-mediated connective disease characterized by skin fibrosis, microvascular damage, and multisystem manifestations. One of the most important processes in connective tissue disorders is vasculitis. The clinical findings can differ when the disease is presented with an antineutrophil cytoplasmic antibody.
View Article and Find Full Text PDFNeurology
October 2025
Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Background And Objectives: Years before diagnosis of Parkinson disease (PD), dementia with Lewy bodies (DLB), or multiple system atrophy (MSA), mild prodromal manifestations can be detected. Longitudinal follow-up of people with prodromal synucleinopathy, particularly idiopathic/isolated REM sleep behavior disorder (iRBD), enables in-depth clinical phenotyping of early disease, which could facilitate stratification for clinical trials, provide the definition of appropriate end points, or predict phenoconversion more precisely. The aim of this study was to update and expand on previous studies assessing clinical evolution from iRBD to clinically diagnosed disease, up to 14 years before diagnosis.
View Article and Find Full Text PDFVestn Oftalmol
September 2025
National Medical Research Center for Endocrinology, Moscow, Russia.
Objective: This study presents a comparative analysis of outcomes of lateral orbital wall decompression performed using ultrasonic bone removal with standard and modified techniques.
Material And Methods: The study included 78 patients (109 orbits) with exophthalmos without visual impairment (subgroups 1A and 1B) and with optic neuropathy (ON) due to thyroid eye disease (TED) (subgroups 2A and 2B). Lateral wall decompression (LWD) was performed using ultrasonic bone removal with a modified (=58, patient subgroups 1A and 2A) or standard (=51, subgroups 1B and 2B) technique.
Clin Ophthalmol
August 2025
University of Virginia School of Medicine, Charlottesville, VA, USA.
Purpose: Diabetic retinopathy (DR) is a leading cause of vision loss in working-age adults. Despite the importance of early DR detection, only 60% of patients with diabetes receive recommended annual screenings due to limited eye care provider capacity. FDA-approved AI systems were developed to meet the growing demand for DR screening; however, high costs and specialized equipment limit accessibility.
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