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Objectives: Suboptimal intrapartum electronic fetal heart rate monitoring using cardiotocography has remained a persistent problem (EFM-CTG). We aimed to identify the range of influences on the safety of using EFM-CTG in practice.
Design: Scoping review to identify influences related to the practice of intrapartum EFM.
Data Sources: MEDLINE, Embase, CINAHL, Web of Science, Scopus, British Nursing Index, Cochrane Library, from 1 January 2001 to 25 August 2024, and grey literature.
Eligibility Criteria: Articles that reported potential influences on the clinical practice of intrapartum EFM-CTG in hospital-based intrapartum maternity care settings, including primary studies, secondary analyses, reviews, reports, conference abstracts and investigations relevant to maternity and obstetrics, in English. Evaluations of technological modifications to traditional EFM-CTG monitoring and analysis were excluded.
Data Extraction And Synthesis: We extracted influences on EFM-CTG from the included studies. Findings were synthesised using a best-fit framework approach, structured using an existing 19-domain framework of contributory factors for patient safety incidents in hospitals.
Results: 142 articles and 14 reports were included. Our synthesis identified influences on EFM practice across all 19 domains of the contributory factors framework, including those relating to cognitive, social and organisational factors and interactions between professional work and tools used for fetal monitoring.
Conclusion: Reducing avoidable harm associated with electronic fetal monitoring requires a systems approach based on a sound understanding of the full range of influences on practice.
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http://dx.doi.org/10.1136/bmjopen-2024-085827 | DOI Listing |
Rev Med Interne
September 2025
Service de médecine interne, centre hospitalier universitaire de Poitiers, 2, rue de la Milétrie, 86000 Poitiers, France; Université de médecine et de pharmacie, université de Poitiers, Poitiers, France; Inserm U1313, université de Poitiers, Poitiers, France.
Introduction: Many women of childbearing age are being treated for chronic conditions that require long-term medication. We assessed the knowledge of women being treated in internal medicine and clinical immunology, regarding the impact of their disease and specific treatments on a potential pregnancy.
Methods: Between September 1st, 2019, and November 1st, 2020, in four hospitals in the Poitou-Charentes region, a questionnaire was given to every woman aged 18 to 44 who came in for an internal medicine and clinical immunology consultation for the follow-up of a chronic systemic disease.
J Allergy Clin Immunol Pract
September 2025
Department of Pediatric Allergy and Immunology, Ege University Faculty of Medicine, Izmir, Turkiye.
Background: In recent years, it has been argued that eosinophilic esophagitis (EoE) seen in the early period of oral immunotherapy (OIT) may also exist before OIT.
Objective: We sought to evaluate the presence of EoE before initiating OIT and identify risk factors (during fetal development, infancy, and environmental exposures) for its development.
Methods: 48 patients who underwent endoscopic evaluation before OIT were enrolled.
NanoImpact
September 2025
Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwa
Microplastic particulates (MPs) accumulate widely in ecosystems and pose health risks to both pregnant women and their offspring. Studies have detected MPs in the kidneys and fetal tissues, but it remains unclear whether maternal MP exposure worsens postnatal MP-induced hypertension and kidney disease. This study examined male rat offspring (n = 8/group) divided into four exposure groups: control, indirect (maternal exposure to 1 mg/L MPs during gestation and lactation), direct (offspring exposure to 1 mg/L MPs from 3 to 16 weeks), and combined exposure.
View Article and Find Full Text PDFAm J Obstet Gynecol
September 2025
Departments of Internal Medicine-Rheumatology and Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, United States. Electronic address:
Pregnancies in patients with systemic lupus erythematosus (SLE) and those positive for anti-SSA/SSB or antiphospholipid antibodies carry a heightened risk of adverse pregnancy outcomes (APOs), including preeclampsia, preterm birth, and congenital heart block. Among available therapies, hydroxychloroquine (HCQ) plays a pivotal role due to its immunomodulatory and antithrombotic properties, which may help improve pregnancy outcomes. Emerging evidence supports HCQ's role in reducing SLE flares, as well as lowering the recurrence risk of congenital heart block in anti-SSA/SSB-positive pregnancies.
View Article and Find Full Text PDFBiol Psychiatry
September 2025
Developmental Neuroscience and Neurogenetics Program, The Saban Research Institute, Los Angeles, CA; Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, Canada; Division of Endocrinology, Children's Hospital LA, Los Angeles, CA; Department of Pediatrics, Keck Scho
Background: Exposure to early life adversity (ELA), including childhood maltreatment, is one of the most significant risk factors for the emergence of psychosomatic disorders in adolescence and adulthood. Most investigations into biological processes that have been perturbed by ELA have profiled DNA methylation in whole blood and coalesced around perturbations of immunobiology being centrally insulted by ELA.
Methods: To identify novel molecular signatures that are enduringly perturbed by childhood maltreatment, we isolated circulating extracellular vesicles (EVs) from plasma collected from adolescent rhesus macaques that had either experienced nurturing maternal care (CONT, n = 7, 4M 3F) or maltreatment in infancy (MALT, n = 6, 3M 3F).