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http://dx.doi.org/10.1164/rccm.202407-1475VP | DOI Listing |
Clin Microbiol Infect
September 2025
Department of Internal Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE.
Background: The pursuit of personalized medicine has underscored the critical role of phenotypes and sub-phenotypes in biology and medicine. A growing body of literature has identified diverse phenotypic manifestations of SARS-CoV-2 influenced by host and viral factors.
Objectives: To assess and integrate current knowledge regarding the clinical, immunologic, and molecular phenotypes associated with COVID-19, highlighting their impact on disease management, the personalization of therapeutic strategies, and the advancement of clinical research.
Crit Care
August 2025
Department of Laboratory Medicine, Biomedical Center, Lund University, BMC C14, Lund, Sweden.
Sepsis remains a leading cause of mortality worldwide, driven by its clinical complexity and delayed recognition. Artificial intelligence (AI) offers promising solutions to improve sepsis care through earlier detection, risk stratification, and personalized treatment strategies. Key applications include AI-driven early warning systems, subphenotyping based on clinical and biological data, and decision support tools that adapt to real-time patient information.
View Article and Find Full Text PDFBiomed Pharmacother
August 2025
Dep. Biochemistry and Molecular Biology, University of Valencia, Valencia 46010, Spain; CIBER of Hepatic and Digestive Diseases, Madrid 28029, Spain; Joint Research Unit in Experimental Hepatology, Health Research Institute Hospital La Fe, Valencia 46026, Spain. Electronic address:
Background: Drug-induced liver injury (DILI) is a rare but serious adverse drug reaction with a wide range of clinical presentations. While three major DILI phenotypes-hepatocellular, cholestatic, and mixed-are well established, other injury patterns such as steatosis-associated DILI (DIS) are harder to identify and remain underexplored. Existing limited evidence suggests that steatosis is frequent among DILI patients, yet this subtype and its causative drugs have not been systematically characterized in large patient cohorts.
View Article and Find Full Text PDFNat Commun
July 2025
Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Infections of the dental pulp are common sequelae of microbial activity and host susceptibility, affecting >80% of adult population. We performed a genome-wide association study on endodontic infections utilizing Finnish health registry and genotype data from FinnGen. Cases [132,124 (27.
View Article and Find Full Text PDFAm J Respir Crit Care Med
September 2025
Kidney Research Institute, Division of Nephrology, Department of Medicine.
Biological heterogeneity in critical illness syndromes, such as sepsis and acute kidney injury (AKI), has hindered development of effective therapies. In sepsis-associated AKI, two molecular subphenotypes (SP1 and SP2) have been identified with differing characteristics, outcomes, and response to vasopressor treatment. It is unknown if these subphenotypes extend to all patients with sepsis and whether they respond differently to fluid resuscitation strategy.
View Article and Find Full Text PDF