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, a rare human pathogen, has limited clinical data. This case report presents a case of sepsis, pyelonephritis, and septic spondylitis treated successfully with ampicillin. An 82-year-old woman was hospitalized for acute pyelonephritis and sepsis, presenting with fever and abdominal pain. After admission, her back pain appeared, and magnetic resonance imaging revealed septic spondylitis of the lumbar spine. Blood and urine cultures obtained at admission revealed the presence of . After six weeks of ampicillin treatment, her symptoms resolved, and she was transferred to a rehabilitation hospital. Retrospectively, a computed tomography scan on admission revealed signs of septic spondylitis, indicating that the patient may have had spondylitis before developing pyelonephritis. , a rare cause of infection in various organs, responded well to ampicillin. Despite its rarity, spondylitis should be considered in the elderly with low back pain and pyelonephritis for a complete differential diagnosis.
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http://dx.doi.org/10.7759/cureus.75501 | DOI Listing |
Front Pharmacol
April 2025
Department of Pharmacy, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Objective: One of the adverse events of greatest concern in patients receiving biologic therapies is the risk of infection, as infections are among the primary causes of premature mortality in this population, especially in the elderly. Because of the absence of head-to-head studies and limited duration and sample size of randomized controlled trials in the older adults, we analyzed the risk of infection associated with tumor necrosis factor (TNF) inhibitors by real-world adverse event analysis, seeking to identify medications with a reduced risk of infection and offering medication options for sensitive patients.
Methods: A retrospective pharmacovigilance investigation was undertaken utilizing the FDA Adverse Event Reporting System (FAERS) database from the first quarter of 2010 to the fourth quarter of 2023.
J Autoimmun
March 2025
School of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, Ontario, Canada. Electronic address:
Objectives: Tumor necrosis factor receptor-associated factor 1 (TRAF1) is an immune signaling adapter protein linked to increased susceptibility to rheumatoid arthritis (RA). TRAF1 has dual roles in regulating NF-κB and MAPK signaling: it promotes signaling through its association with cellular inhibitor of apoptosis 2 (cIAP2) downstream of certain tumor necrosis factor receptor (TNFR) family members but inhibits Toll-like receptor (TLR) signaling by limiting linear ubiquitination of key signaling proteins. In this study, we investigated whether selectively targeting TRAF1/cIAP2 interaction would lower inflammation and reduce severity of RA.
View Article and Find Full Text PDFCureus
December 2024
Emergency Medicine, Nagasaki Harbor Medical Center, Nagasaki, JPN.
, a rare human pathogen, has limited clinical data. This case report presents a case of sepsis, pyelonephritis, and septic spondylitis treated successfully with ampicillin. An 82-year-old woman was hospitalized for acute pyelonephritis and sepsis, presenting with fever and abdominal pain.
View Article and Find Full Text PDFZ Rheumatol
May 2025
Klinik für internistische Rheumatologie, Rotes Kreuz Krankenhaus, St.-Pauli-Deich 24, 28199, Bremen, Deutschland.
Inn Med (Heidelb)
January 2025
Sektion Pneumologie, Medizinische Klinik I, Sana Kliniken, Lübeck, Deutschland.
A young man presented with exertional dyspnea and thoracic pain following pharyngitis. The findings included pulmonary melting, left-sided pleural empyema and spondylitis. Cultures for detection of the pathogen were negative and sequencing for bacterial DNA was additionally carried out resulting in detection of Fusobacterium necrophorum that is typical for oropharyngeal infections.
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