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http://dx.doi.org/10.1016/j.jcin.2024.10.010 | DOI Listing |
ACS Nano
September 2025
School of Mechanical Engineering, Southeast University, Nanjing 211189, People's Republic of China.
Nitrogen-vacancy (NV) centers in diamond demonstrate advantages in biosensing due to their exceptional photostability and long spin coherence time. However, clinical applications of NV centers are significantly limited because their spin states lack responsiveness to nonmagnetic biomolecules. This work presents a nanocatalytic-amplified quantum sensing platform targeting tyrosinase (TYR), a key biomarker for melanoma.
View Article and Find Full Text PDFEMBO Rep
August 2025
Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Direct visualization of HIV-1 nuclear import through the nuclear pore complex (NPC) presents a technical challenge due to the rarity of this process. To enable systematic investigation, we developed a robust in situ system that mimics HIV-1 nuclear import in a near-native context using isolated HIV-1 virus like particles (VLP) cores and permeabilized CD4 + T lymphocyte (CEM) cells. This approach supports docking and translocation of abundant viral cores through nuclear pores into the nucleus.
View Article and Find Full Text PDFNano Lett
September 2025
Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW 2234, Australia.
A complete picture of the unique lattice dynamics of nanocrystals is slowly being painted with contributions from a variety of techniques. How these unique dynamics change when the nanocrystals are embedded in a matrix, however, is not well explored. We systematically compare the phonon spectra of diamond nanocrystals before and after embedding in a tin telluride matrix.
View Article and Find Full Text PDFFreeform optics has emerged as a significant design tool over the past decade. Non-rotationally symmetric optical surfaces enable high-performance imaging systems to achieve a large field of view (FOV), high resolution, low distortion, lightweight construction, and compact structure simultaneously. Advances in single-point diamond-turning fabrication and computer-generated hologram (CGH)-based metrology are gradually making optical imaging with freeform optics more practical.
View Article and Find Full Text PDFPhys Rev Lett
July 2025
University of Chicago, Pritzker School of Molecular Engineering, Chicago, Illinois 60637, USA.
Optically active spin defects in solids are promising platforms for quantum technologies. Here, we present a first-principles framework to investigate intersystem crossing processes, which represent crucial steps in the optical spin-polarization cycle used to address spin defects. Considering the nitrogen-vacancy center in diamond as a case study, we demonstrate that our framework effectively captures electron correlation effects in the calculation of many-body electronic states and their spin-orbit coupling and electron-phonon interactions, while systematically addressing finite-size effects.
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