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http://dx.doi.org/10.1016/j.chest.2024.09.034 | DOI Listing |
Gastric Cancer
September 2025
Department of Medical Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Background: Immune checkpoint inhibitors (ICIs) play a pivotal role in the treatment of advanced gastric cancer (GC). However, the biomarkers used to predict ICI efficacy are limited due to their reliance on single or static tumor characteristics. This study aims to develop a machine learning (ML) model that incorporates dynamic changes in clinlabomics data to optimize the predictive accuracy of ICI efficacy.
View Article and Find Full Text PDFJ Relig Health
September 2025
Center for Climate Action and Social Transformations (4CAST) Institute of Psychology, SWPS University, Warsaw, Poland.
The present study examined responses to COVID-19 at the beginning of the pandemic, April 2020, among a representative sample of 880 Poles. Participants described their religious beliefs, their emotional reactions to the pandemic, the changes they had made in their behavior since the onset of the pandemic, and their political orientation (left-right). Roman Catholics felt more threatened by the pandemic than non-believers, and Catholics reacted more strongly to the pandemic than non-believers in terms of feeling scared, paralyzed by fear, panicked, fearful, sad, woebegone, and lost, whereas there were no such differences on other emotional reactions.
View Article and Find Full Text PDFMil Med
September 2025
School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia.
Introduction: Submarine environments pose unique challenges to maintaining physical activity and exercise routines due to confined spaces, demanding schedules, and limited resources. This study investigated submariners' physical activity patterns, sleep quality, and perceived exercise barriers in both land- and sea-based settings, with the goal of informing targeted health interventions.
Materials And Methods: Ethics approval was granted by the Defence Science and Technology Group and Edith Cowan University review panels.
Inflamm Bowel Dis
September 2025
IBD Unit, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Italy.
Background: The infliximab (IFX) biosimilar, CT-P13, is available as an intravenous (IV) and subcutaneous (SC) formulation. Although current indications allow the transition from IV CT-P13 to SC CT-P13 after two IV administrations, some clinicians prefer to postpone switching until stable clinical remission has been achieved.
Methods: We evaluate the endoscopic response, treatment persistence, clinical remission, endoscopic remission, and safety profile after one year of treatment with IFX in patients switched from IV to SC after 6 weeks (early switch group) or after 6 months (late switch group).