Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The mechanisms that determine distinct embryonic pallial identities remain elusive. The central role of Wnt signaling in directing dorsal telencephalic progenitors to the isocortex or hippocampus has been elucidated. Here, we show that timely inhibition of MAPK/ERK and BMP signaling in neuralized mouse embryonic stem cells (ESCs) specifies a cell identity characteristic of the allocortex. Comparison of the global gene expression profiles of neural cells generated by MAPK/ERK and BMP inhibition (MiBi cells) with those of cells from early postnatal encephalic regions reveals a pallial identity of MiBi cells, distinct from isocortical and hippocampal cells. MiBi cells display a unique pattern of gene expression and connectivity, and share molecular and electrophysiological features with the entorhinal cortex. Our results suggest that early changes in cell signaling can specify distinct pallial fates that are maintained by specific neuronal lineages independent of subsequent embryonic morphogenetic interactions and can determine their functional connectivity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864161 | PMC |
| http://dx.doi.org/10.1016/j.stemcr.2024.12.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Alcohol activates ATF4/LPLA2-mediated BMP metabolism to enhance HBV-induced hepatocellular carcinogenesis.
J Hepatol
August 2025
Department of Gastroenterology, Alcohol-related Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, 510630 Guangzhou, China; Guangdong Provincial Key Laboratory of Liver Disease Research, 510630 Guangzhou, China. Electronic address:
Background & Aim: Chronic alcohol consumption synergistically enhances hepatocellular carcinoma (HCC) risk in hepatitis B virus (HBV)-infected individuals. However, the pivotal molecular mechanisms still remain elusive.
Methods: HBx-transgenic (HBx-Tg) mice and nude mouse xenograft models were used to evaluate the tumor-promoting effects of ethanol.
The Influence of Vitamin C-incorporated Polycaprolactone on Osteogenesis in Osteoblast-Osteoclast Co-culture In Vitro.
Int Dent J
August 2025
Oral & Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates. Electronic address:
Objectives: Implantation of biomaterials generates reactive oxygen species (ROS) in the peri-implant microenvironment. Bone loss occurs when ROS levels exceed the local antioxidant capacity. The aim of this study was to investigate the influence of vitamin C-incorporated polycaprolactone (PCL-Vit C) membrane in scavenging ROS and enhancing biomineralisation in osteoblast-osteoclast (OB-OC) co-culture system.
View Article and Find Full Text PDFDual inhibition of MAPK/ERK and BMP signaling induces entorhinal-like identity in mouse ESC-derived pallial progenitors.
Stem Cell Reports
February 2025
Laboratorio di Biologia, Scuola Normale Superiore, 56126 Pisa, Italy; Istituto di Biofisica, Consiglio Nazionale delle Ricerche, 56124 Pisa, Italy. Electronic address:
The mechanisms that determine distinct embryonic pallial identities remain elusive. The central role of Wnt signaling in directing dorsal telencephalic progenitors to the isocortex or hippocampus has been elucidated. Here, we show that timely inhibition of MAPK/ERK and BMP signaling in neuralized mouse embryonic stem cells (ESCs) specifies a cell identity characteristic of the allocortex.
View Article and Find Full Text PDFIn vitro reconstitution of epigenetic reprogramming in the human germ line.
Nature
July 2024
Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Epigenetic reprogramming resets parental epigenetic memories and differentiates primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia. This process ensures sexually dimorphic germ cell development for totipotency. In vitro reconstitution of epigenetic reprogramming in humans remains a fundamental challenge.
View Article and Find Full Text PDFXbra modulates the activity of linker region phosphorylated Smad1 during Xenopus development.
Sci Rep
April 2024
Department of Biochemistry, Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon, Gangwon-Do, 24252, Republic of Korea.
The Bmp/Smad1 pathway plays a crucial role in developmental processes and tissue homeostasis. Mitogen-activated protein kinase (Mapk)/Erk mediated phosphorylation of Smad1 in the linker region leads to Smad1 degradation, cytoplasmic retention and inhibition of Bmp/Smad1 signaling. While Fgf/Erk pathway has been documented to inhibit Bmp/Smad1 signaling, several studies also suggests the cooperative interaction between these two pathways in different context.
View Article and Find Full Text PDF