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Cosmetic procedures carry inherent risks of adverse events. Though rarely reported, transient and permanent alopecia are potential complications of these procedures. We report the case of a 35-year-old woman who developed pain and patches of nonscarring alopecia with erythema and edema following aesthetic application of poly-L-lactic acid (PLLA) on the face and along the frontal hairline. Trichoscopy and histopathologic analysis confirmed the diagnosis. Dermatologists should be aware of the potential for embolization and retinal ischemia following the use of PLLA. Moreover, trichoscopy combined with histopathologic analysis should be encouraged to improve early recognition and proper management of this rare adverse event.
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http://dx.doi.org/10.12788/cutis.115 | DOI Listing |
J Mech Behav Biomed Mater
August 2025
School of Mechanical Engineering, Jiangsu Key Laboratory for Design and Manufacturing of Precision Medicine Equipment, Southeast University, Nanjing, 211189, China. Electronic address:
Poly(L-lactic acid) (PLLA), as a substrate material, has been widely utilized in the field of biodegradable vascular stents. Prior to implantation, it is particularly crucial for these devices to assess the relationship of the mechanical properties and microstructures during full degradation cycle. Although previous studies have primarily focused on structural parameters such as crystallinity and molecular weight, there are relatively few reports that explore the impact of microstructure on mechanical performance from the perspective of chain configuration during the degradation.
View Article and Find Full Text PDFCarbohydr Polym
November 2025
Department of Polymers for Health and Biomaterials, IBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France; Department of Pharmacy, Nîmes University Hospital, 30900 Nimes, France. Electronic address:
Polysaccharide-based hydrogels often lack mechanical strength and, when used for protein delivery, are generally limited to diffusion-based release. In this work, we developed robust polysaccharide- and polyester-based near-infrared (NIR)-responsive hydrogels. Hydrogels are made from photo-crosslinked methacrylated dextran (DEX-MA), methacrylated polylactide containing oxygen reactive species (ROS) sensitive thioketal groups (PLA-TK-MA), and covalently bound protoporphyrin IX (PPIX) that generates ROS under NIR irradiation.
View Article and Find Full Text PDFACS Macro Lett
September 2025
State Key Laboratory of Advanced Polymer Materials, Polymer Research Institute of Sichuan University, Chengdu 610065, China.
Typically, specific amide nucleating agents (NAs) that can form nanofibrous networks by self-assembly are vital to achieve poly(l-lactic acid) (PLA) with good heat resistance and transparency. However, the long time required for self-assembly during rapid cooling results in a narrow crystallization window for induced PLA, thus requiring a combination of high annealing temperature and a long annealing time. Herein, a synergistic nucleation strategy was introduced to address this challenge, i.
View Article and Find Full Text PDFACS Appl Bio Mater
September 2025
Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies (IMEM-BRT) Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, C/Eduard Maristany 10-14, Building I, second floor, Barcelona 08019, Spain.
A drug delivery platform based on highly porous poly(lactic acid) (PLA) microparticles functionalized with amphiphilic poly(ethylene glycol)-cholesterol (PEG-Chol) has been developed and successfully validated . This hybrid system addresses key limitations of conventional PLA and poly(lactide--glycolide) (PLGA) nanoparticles, providing better encapsulation and sustained drug release. The incorporation of PEG-Chol provides both enhanced aqueous dispersibility for prolonged circulation and membrane-anchoring capabilities, thereby promoting cellular interaction and endocytosis.
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