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Objectives: The Bioethics Law of August 2nd, 2021 established access to origins for people conceived by gamete donation. Two years after the implementation of this disposition, what is the proportion of former gamete donors informed about access to origins, and what is their position on this matter? What could be the potential repercussions of this new law on them?
Methods: Retrospective single-center cohort study using questionnaires.
Results: When former gamete donors were asked about access to origins, only 53% of oocytes donors and 71% of sperm donors were aware of this measure. When participants were asked about the ideal method of donation, it emerged that 41% of female donors and 47% of male donors were in favour of access to their identifying data for the person resulting from the donation. More than half were in favour of access to non-identifying and medical data. If one day someone conceived from their donation requested access to their identifying data, 62% of oocytes donors and 56% of sperm donors would grant it.
Conclusions: A significant proportion of our participants expressed the desire to benefit from information on possible descendants resulting from their donation. Among the donors interviewed, only half are informed of the legislation introducing access to origins, now two years after its implementation. These results encourage us to strengthen communication efforts around access to origins.
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http://dx.doi.org/10.1016/j.gofs.2024.12.005 | DOI Listing |
Ophthalmic Plast Reconstr Surg
September 2025
Purpose: During endoscopic endonasal access to small intraconal masses deep in the orbital apex, a line of fusion between inferior and medial recti is encountered distal to the termination of the common tendinous ring. The intraoperatively viewed length of this segment has not been quantified. To assist clinical recognition of this structure, our study quantifies its length and proposes the standardized nomenclature term of inferomedial extraocular muscle raphe (IM-EOMR).
View Article and Find Full Text PDFJ Org Chem
September 2025
State Key Laboratory of Chemical Resource Engineering, Institute of Computational Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.
The -di(2-pyridyl)arenes, featuring a unique structure, hold significant promise for applications in fluorescent probes, synthetic nanoparticle stabilizers, and chemical synthesis. The mechanism of Ru-catalyzed decarboxylation and heteroarylation reactions of aryl carboxylic acids to access -dipyridylarenes was elucidated using DFT calculations, which involved C-H bond activation, oxidative addition, reductive elimination, and decarboxylation processes to form -di(2-pyridyl)arenes. The rate-determining step of the reaction is the second reductive elimination step with an energy barrier of 27.
View Article and Find Full Text PDFJ Robot Surg
September 2025
Department of Research and Innovation, Medway NHS Foundation Trust, Gillingham, ME7 5NY, UK.
Robotic surgery has transformed the field of surgery, offering enhanced precision, minimal invasiveness, and improved patient outcomes. This narrative review explores the multifaceted aspects of robotic surgery, examining the challenges, recent advances, and future prospects for its integration into healthcare. Our comprehensive analysis of 48 studies reveals significant geographic disparities in robotic surgery research and implementation, with 68.
View Article and Find Full Text PDFNat Prod Rep
September 2025
Saarland University, Department of Pharmacy, Saarbrücken, Germany.
Focus on 2004 to 2024The rediscovery of natural products (NPs) as a critical source of new therapeutics has been greatly advanced by the development of heterologous expression platforms for biosynthetic gene clusters (BGCs). Among these, species have emerged as the most widely used and versatile chassis for expressing complex BGCs from diverse microbial origins. In this review, we provide a comprehensive analysis of over 450 peer-reviewed studies published between 2004 and 2024 that describe the heterologous expression of BGCs in hosts.
View Article and Find Full Text PDFTrauma Surg Acute Care Open
September 2025
Medical Center of the Rockies, Loveland, Colorado, USA.
Introduction: Efforts to strengthen healthcare systems have led to the development of clinical practice guidance, defined as clinical decision-making aids built on scientific evidence, experiential knowledge, and ideally, patient values. This review evaluates the accessibility, relevance, and quality of existing trauma guidance globally.
Methods: A systematic review evaluated trauma-related clinical guidance sources published from 2016 to 2023, searching in English across eight databases and 28 professional society websites.