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http://dx.doi.org/10.1073/pnas.2411917121 | DOI Listing |
Circulation
September 2025
Division of Cardiology, Columbia University Irving Medical Center, New York, NY (S.A.P.).
Background: Limited treatment options exist for infrapopliteal disease in patients with chronic limb-threatening ischemia (CLTI), a condition associated with a high risk of limb loss. Interventional management of diseased infrapopliteal vessels with percutaneous transluminal angioplasty (PTA) is associated with high rates of restenosis and reintervention. In the LIFE-BTK trial, the drug-eluting resorbable scaffold (DRS) demonstrated superior 12-month efficacy compared with PTA in a selected CLTI population with predominantly noncomplex, mildly to moderately calcified lesions.
View Article and Find Full Text PDFBayesian Anal
January 2025
Department of Statistics, University of Washington, Seattle, USA.
We introduce the BREASE framework for the Bayesian analysis of randomized controlled trials with binary treatment and outcome. Approaching the problem from a causal inference perspective, we propose parameterizing the likelihood in terms of the aseline isk, fficacy, and dverse ide ffects of the treatment, along with a flexible, yet intuitive and tractable jointly independent beta prior distribution on these parameters, which we show to be a generalization of the Dirichlet prior for the joint distribution of potential outcomes. Our approach has a number of desirable characteristics when compared to current mainstream alternatives: (i) it naturally induces prior dependence between expected outcomes in the treatment and control groups; (ii) as the baseline risk, efficacy and risk of adverse side effects are quantities commonly present in the clinicians' vocabulary, the hyperparameters of the prior are directly interpretable, thus facilitating the elicitation of prior knowledge and sensitivity analysis; and (iii) we provide analytical formulae for the marginal likelihood, Bayes factor, and other posterior quantities, as well as an exact posterior sampling algorithm and an accurate and fast data-augmented Gibbs sampler in cases where traditional MCMC fails.
View Article and Find Full Text PDFGlob Ment Health (Camb)
July 2025
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Problem-solving therapy (PST) is a brief psychological intervention often implemented for depression. Currently, there are no tools with well-evidenced reliability to measure PST fidelity. This pilot study aimed to measure the inter-rater reliability and agreement of the blem-Slving Therapy idelity (PROOF) scale, comprising binary 14-item adherence and an 8-item competence subscales.
View Article and Find Full Text PDFBackground: Global evidence has observed that individuals with inflammatory bowel disease (IBD) are at a heightened risk of experiencing psychiatric disorders, which often coincide with a decrease in their quality of life.
Objective: To assess the prevalence of anxiety and depression symptoms and associated factors among patients with IBD.
Methods: An institutional-based cross-sectional study was conducted at Tikur Anbesa Specialized Hospital and Adera Medical Center.
Front Psychiatry
August 2025
Department of Psychiatry, Nagoya City University East Medical Center, Nagoya, Japan.
Although post-earthquake psychological distress arises from a complex interplay of personal vulnerabilities and environmental stressors, the pathways by which these factors interact remain underexplored. We surveyed 327 hospital nurses in Nanao City, Japan, approximately eight months after the magnitude-7.5 2024 Noto Peninsula earthquake; 224 complete responses were analyzed.
View Article and Find Full Text PDF