Article Synopsis
- After RFA treatment for liver cancer, there's a notable increase in the expression of /xCT and the number of dendritic cells (DCs) in the tumor microenvironment (TME).
- /xCT is associated with poor prognosis in liver cancer and is primarily found in DCs within the TME.
- Combining xCT targeting in DCs with RFA treatment boosts anti-tumor immune responses, reduces tumor growth, and suggests a potential strategy for better treatment outcomes in liver cancer.
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Article Abstract
After RFA treatment in patients with liver cancer, the expression of /xCT and the proportion of DCs in the TME were significantly increased. /xCT is a poor prognostic marker for liver cancer and is mainly expressed in DCs in the TME. Targeting xCT in DCs combined with RFA significantly enhances anti-tumor immunity, suppressing tumor growth and offering a promising strategy for improved therapeutic outcomes in liver cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683471 | PMC |
| http://dx.doi.org/10.1002/imt2.248 | DOI Listing |
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