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http://dx.doi.org/10.1016/j.mayocp.2024.11.005 | DOI Listing |
JACC Case Rep
September 2025
Division of Cardiovascular Imaging, Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Background: Lipomatous hypertrophy of the interatrial septum (LHIS) is a benign cardiac lesion characterized by excessive fat accumulation in the interatrial septum, often sparing the fossa ovalis. Although typically asymptomatic, severe cases may lead to hemodynamic compromise.
Cases Summary: We report 2 cases of exuberant symptomatic LHIS requiring surgical intervention.
J Cardiovasc Dev Dis
August 2025
Department Radiology, Innsbruck Medical University, 6020 Innsbruck, Austria.
While epicardial adipose tissue (EAT) is a known predictor of adverse cardiovascular outcomes, lipomatous hypertrophy of the interatrial septum (LHIS) is composed of metabolically active fat such as brown adipose tissue, which may exert a different effect. This study investigates the coronary atherosclerosis profile in patients with LHIS using CTA, compared with a propensity score-matched control group. A total of 142 patients were included ( = 71 with LHIS and = 71 controls) and propensity score-matched for age, gender, BMI, and the major CV risk factors (matching level, <0.
View Article and Find Full Text PDFJACC Case Rep
August 2025
Lee Health Heart Institute, Fort Myers, Florida, USA.
Background: Lipomatous hypertrophy of the interatrial septum (LHIS) is a benign cardiac tumor involving nonencapsulated fat. While usually asymptomatic, it may rarely lead to hemodynamic compromise.
Case Summary: An 83-year-old man with ischemic cardiomyopathy presented with worsening dyspnea.
Ann Nucl Med
July 2025
Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.
Purpose: Brown adipose tissue (BAT) contributes to thermoregulation and energy expenditure. Although BAT is abundant in early childhood and declines with age, its distribution across age groups remains unclear. This study examined age-related BAT distribution using fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT).
View Article and Find Full Text PDFJACC Case Rep
July 2025
Department of Interventional Cardiology, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.
A 71-year-old woman presented with dyspnea on exertion. Subsequent evaluation identified lipomatous hypertrophy of the interatrial septum (LHIS), which had findings of hypermetabolic activity owing to the presence of brown fat in the interatrial septum. LHIS is a rare condition and is typically considered to be a benign incidental finding.
View Article and Find Full Text PDF