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Background With the rising number of children with congenital heart disease (CHD) reaching adulthood, surgical intervention has become a critical aspect of their long-term management. This study presents a six-year overview of early postoperative outcomes and mortality in CHD surgeries at a single center, underscoring advancements and challenges in treating this complex population. Objective As more children with CHD grow into adulthood, we are gaining critical insights from our extensive experience in performing cardiac surgery for this population. This report details our six-year experience at a single center, highlighting short-term outcomes and in-hospital mortality rates. Methods We collected data on all consecutive patients with CHD who underwent surgery between July 2018 and September 2024 in the Cardiac Surgery Department at Hayatabad Medical Complex, Peshawar, Pakistan. We evaluated early outcomes, including ventilation duration, length of intensive care unit (ICU) stay, total hospital stay, and mortality rates. Results A total of 250 procedures were performed on patients, with a mean age of 22.98 years (Range 1-78 years); 48.4% were male and 51.6% were female. Re-do procedures accounted for 2.4% of the total procedures. The most common procedures involved repair of septal defects (43.8%), right heart lesions (19.2%), and thoracic arterial and venous surgeries (16.8%). While the primary procedures involved less complex cases, they included 15.2% tetralogy of Fallot repairs, 4.0% aortic coarctation repairs, and 1.2% repairs for Ebstein's disease. In-hospital mortality was recorded at 1.6%, with an overall survival rate of 98.4%. Conclusion Surgery in patients with CHD can be performed with low operative mortality and favorable clinical outcomes. Our findings demonstrate that, despite the complexities inherent to this population, most procedures yield successful results, contributing to a high overall survival rate. This underscores the importance of specialized surgical approaches and continuous management for CHD patients, emphasizing the potential for positive long-term outcomes in this growing demographic.
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http://dx.doi.org/10.7759/cureus.74688 | DOI Listing |
J Trace Elem Med Biol
September 2025
Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, Kraków 31-343, Poland. Electronic address:
Vanadium (V) is a trace element in the environment; it is detected in soil, water, air, dust, and food products. V-containing compounds have shown therapeutic potential in the treatment of diabetes. However, studies on the effects of V on animal behavior remain limited and sporadic.
View Article and Find Full Text PDFACS Appl Bio Mater
September 2025
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
The generation of reactive oxygen species (ROS) through nanozyme-mediated sonocatalytic therapy has demonstrated remarkable therapeutic efficacy in the field of cancer. Nevertheless, it remains a significant challenge for nanozymes with a single catalytic active center to generate sufficient ROS via Fenton or Fenton-like reactions to effectively induce tumor cell death. In order to enhance the catalytic efficacy, we devised and synthesized a multiple active centre and mitochondrial-targeted perovskite nanozyme (NCFP), doped with cobalt (Co) element, and incorporated 4-carboxybutyltriphenylphosphonium bromide (TPP) as a mitochondrial targeting marker for ultrasound (US)-assisted enzyme-like catalytic treatment of tumors.
View Article and Find Full Text PDFJMIR Cancer
September 2025
iCARE Secure Data Environment & Digital Collaboration Space, NIHR Imperial Biomedical Research Centre, London, United Kingdom.
Background: Electronic health records (EHRs) are a cornerstone of modern health care delivery, but their current configuration often fragments information across systems, impeding timely and effective clinical decision-making. In gynecological oncology, where care involves complex, multidisciplinary coordination, these limitations can significantly impact the quality and efficiency of patient management. Few studies have examined how EHR systems support clinical decision-making from the perspective of end users.
View Article and Find Full Text PDFLangmuir
September 2025
Laboratory of Electrochemistry-Corrosion, Metallurgy and Inorganic Chemistry, Faculty of Chemistry, USTHB, BP 32, 16111, Algiers, Algeria.
Azo dyes, prevalent in various industries, including textile dyeing, food, and cosmetics, pose significant environmental and health risks due to their chemical stability and toxicity. This study introduces the synthesis and application of a copper hydrogen-π-bonded benzoate framework (Cu-HBF) and its derived marigold flower-like copper oxide (MFL-CuO) in a synergetic adsorption-photocatalytic process for efficiently removing cationic azo dyes from water, specifically crystal violet (CV), methylene blue (MB), and rhodamine B (RhB). The Cu-HBF, previously available only in single crystal form, is prepared here as a crystalline powder for the first time, using a low-cost and facile procedure, allowing its application as an adsorbent and also serving as a precursor for synthesizing well-structured copper oxide (MFL-CuO).
View Article and Find Full Text PDFJ Craniofac Surg
September 2025
Division of Plastic and Reconstructive Surgery Medical Center, Los Angeles, CA.
Auricular reconstruction is essential for restoring facial symmetry and achieving a well-contoured, natural-appearing ear. Traditional methods using autologous costal cartilage often delay reconstruction until around age 10, when sufficient rib cartilage is available, which can pose physical and psychological challenges for pediatric patients. Porous high-density polyethylene (PHDPE) implants offer significant advantages, including the ability to perform reconstruction earlier, reduced morbidity, improved ear definition, and the possibility of a single-stage outpatient procedure.
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