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Background: Globally, the Coronavirus disease 2019 (COVID-19) pandemic had a significant impact on mental health. Sudden lifestyle changes, threatening information received through various sources, fear of infection and other stressors led to sleep disturbances such as insomnia. The current study aimed to assess the prevalence of insomnia and its associated risk factors during the first wave of COVID-19 pandemic among Singapore residents.
Methods: A cross-sectional study conducted online and in person, from May 2020 to June 2021, recruited Singapore citizens and permanent residents, aged 21 years and above, fluent in English, Chinese or Malay language. Respondents answered an interviewer-administered questionnaire, including Insomnia Severity Index (ISI), Generalised Anxiety Disorder-7 (GAD-7), Physical Health Questionnaire (PHQ-9), stress scale of the Depression, Anxiety and Stress Scales (DASS), chronic conditions checklist and COVID-19 related stressors (exposure to COVID-19, current and future perceived risk of infection). Chi-squared test followed by stepwise logistic regression analysis were conducted to determine factors associated with insomnia.
Results: The study recruited 1129 respondents. Prevalence of insomnia was noted to be 7.4% in the sample. Insomnia was significantly associated with psychological distress- depression (p < 0.001) and anxiety (p < 0.001), financial loss as a source of stress (p < 0.012), ever been diagnosed with asthma (p < 0.001) and backache (p < 0.002).
Conclusion: Insomnia was prevalent and associated with higher level of psychological distress among Singapore residents. These findings can be utilised to design effective targeted interventions like cognitive behavioural therapy, therapist assisted relaxation and meditation programs to improve sleep and reduce psychological distress. Interventions like these can be delivered via smartphone applications enabling easy access, delivery, and utilization by the vulnerable groups. Overall, these strategies would not only help people maintain better mental health and sleep quality during a pandemic but also build resilience, enhancing society's ability to cope with future crises.
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http://dx.doi.org/10.1186/s12889-024-20820-2 | DOI Listing |
Crit Rev Ther Drug Carrier Syst
January 2025
The emergence of messenger ribonucleic acid (mRNA) vaccines as an alternative platform to traditional vaccines has been accompanied by advances in nanobiotechnology, which have improved the stability and delivery of these vaccines through novel nanoparticles (NPs). Specifically, the development of NPs for mRNA delivery has facilitated the loading, protection and release of mRNA in the biological microenvironment, leading to the stimulation of mRNA translation for effective intervention strategies. Intriguingly, two mRNA vaccines, BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), have been permitted for emergency usage authorization to prevent COVID-19 infection by USFDA.
View Article and Find Full Text PDFJ Occup Environ Hyg
September 2025
Department of Environmental Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska.
Powered air-purifying respirators (PAPR) have become an increasingly utilized form of respiratory protection against highly infectious aerosols. In the United States, PAPRs have been used in high-level clinical isolation settings to care for patients infected with viral hemorrhagic fevers and, more recently, during the COVID-19 pandemic. PAPRs have long been used for biocontainment care and experienced increased use during the pandemic because they provide full-face visibility and eye and respiratory protection.
View Article and Find Full Text PDFInteract J Med Res
September 2025
Department of Medicine, MacKay Medical College, New Taipei, Taiwan.
Background: Dengue fever remains the most significant vector-borne disease in Southeast Asia, imposing a substantial burden on public health systems. Global warming and increased international mobility may exacerbate the disease's prevalence. Furthermore, the unprecedented COVID-19 pandemic may have influenced the epidemiological patterns of dengue.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Chulalongkorn University, Bangkok, Thailand.
Background: The interprofessional educational curriculum for patient and personnel safety is of critical importance, especially in the context of the COVID-19 pandemic, to prepare junior multiprofessional teams for emergency settings.
Objective: This study aimed to evaluate the effectiveness of an innovative interprofessional educational curriculum that integrated medical movies, massive open online courses (MOOCs), and 3D computer-based or virtual reality (VR) simulation-based interprofessional education (SimBIE) with team co-debriefing to enhance interprofessional collaboration and team performance using Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS). This study addressed 3 key questions.
JMIR Form Res
September 2025
Department of Psychological Science, School of Social Ecology, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697, United States, 1 203-887-8857.
Background: Rates of loneliness have risen sharply since the onset of the COVID-19 pandemic, largely due to disruptions in social relationships and daily routines, with college students experiencing some of the greatest increases. While prevention programs targeting loneliness have been developed, their success has been limited. One promising approach may lie in enhancing the quality of existing relationships rather than simply increasing social interactions during periods of acute loneliness.
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