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Photofunctional nanomaterials and nanostructures that can emit, manipulate, convert, and utilize photons in diverse forms have profound meanings, from fundamental understandings to applications [...].
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728785 | PMC |
http://dx.doi.org/10.3390/nano14242023 | DOI Listing |
J Control Release
August 2025
Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao, Shandong 266237, PR China. Electronic address:
Achieving multiple antitumor efficacy in a single nanostructure is important for the development of photo-functional nanomedicines. In this paper, we report a direct triplet state energy converter (NCPRB) based on lanthanide nanocrystals, which can reduce the loss of near-infrared (NIR) light and improve the efficiency of generating reactive oxygen species (ROS) to induce ferroptosis through the process of direct energy transfer from rare earth ions (Nd) to the triplet state of the photosensitive molecule (chlorin e6, Ce6). Experimental results showed that the generated ROS combined with loaded resveratrol (RES) inhibited oxidative phosphorylation (OXPHOS) and electron transport chain (ETC) processes in the mitochondria of tumor cells and induced the onset of mitochondrial autophagy.
View Article and Find Full Text PDFNanomaterials (Basel)
December 2024
Center for Future Optoelectronic Functional Materials, School of Computer and Electronic Information/School of Artificial Intelligence, Nanjing Normal University, Nanjing 210023, China.
Photofunctional nanomaterials and nanostructures that can emit, manipulate, convert, and utilize photons in diverse forms have profound meanings, from fundamental understandings to applications [...
View Article and Find Full Text PDFJ Control Release
December 2024
State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianj
Immunotherapy, a pivotal and promising approach for tumor treatment, has demonstrated prominent clinical efficacy. However, its effectiveness is often impeded by insufficient antitumor immune responses attributed to the immunosuppressive tumor microenvironment (TME). The combination of immune activation through the stimulator of interferon genes (STING) pathway and phototherapy holds great potential for surmounting this challenge in advanced tumor immunotherapy.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
February 2025
Department of Physics, CICECO - Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.
The spectroscopic studies of layered rare-earth hydroxides (LRHs) have aroused great interests owing to the unique features of combing rare-earth ions with diverse anions. In this work, some anions were incorporated into layered lutetium-dysprosium hydroxides (LLuH:Dy) by the hydrothermal and ion exchange process, in which Dy ion acted as the emission center. The results manifest that the assemblies possess clearly lamellar structure and flake shape, and emit the characteristic yellow and blue light of Dy under ultraviolet excitation.
View Article and Find Full Text PDFACS Biomater Sci Eng
October 2024
Department of Materials Science and Bioengineering, Graduate School of Engineering, Nagaoka University of Technology, Kamitomioka 1603-1, Nagaoka, Niigata 940-2188, Japan.
We successfully synthesized folic acid (FA) immobilized hydroxyapatite (HA) nanoparticles without using a mediative reagent (e.g., silane coupling agent), and the immobilization states were evaluated and discussed.
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