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Article Abstract
Mutations in the oncogene are recurrently linked to chronic lymphocytic leukemia (CLL), found in approximately 10% of CLL cases at diagnosis. Although these mutations are associated with clinical outcomes, their significance in the context of treatment with anti-CD20 monoclonal antibodies, Bruton's tyrosine kinase inhibitors, and BCL2 inhibitors remains controversial. Consequently, testing for mutations is not recommended outside of a clinical setting. This systematic literature review aims to consolidate the current understanding that mutations are exploratory and not recommended for routine clinical practice.
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| http://dx.doi.org/10.1080/10428194.2024.2441858 | DOI Listing |
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