Sorbitol signaling: Linker histone MdH1.1 modulates malic acid buildup in apple.

Plant Cell

Assistant Features Editor, The Plant Cell, American Society of Plant Biologists.

Published: December 2024


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708836PMC
http://dx.doi.org/10.1093/plcell/koae332DOI Listing

Publication Analysis

Top Keywords

sorbitol signaling
4
signaling linker
4
linker histone
4
histone mdh11
4
mdh11 modulates
4
modulates malic
4
malic acid
4
acid buildup
4
buildup apple
4
sorbitol
1

Similar Publications

Diabetic retinopathy (DR), traditionally considered a microvascular complication, is now recognized as a neuroinflammatory disorder involving retinal glial cells. Aldose reductase (AKR1B1), a key enzyme in the polyol pathway, has been implicated in the hyperglycemia-induced inflammatory response in various cell types, although its role in retinal Müller glial cells under acute glucose stress remains unclear. This study investigates AKR1B1 activity and its contribution to inflammatory signaling in MIO-M1 human Müller cells exposed to acute hyperglycemia.

View Article and Find Full Text PDF

A reproducible ddRAD-seq protocol reveals novel genomic association signatures for fruit-related traits in peach.

Plant Methods

July 2025

Group of Genomics of Fruit Trees and Grapevine, Department of Pomology, Estación Experimental de Aula Dei-Consejo Superior de Investigaciones Científicas, Avenida de Montañana 1005, 50059, Zaragoza, Spain.

Improving peach cultivars with superior traits is a primary objective of breeding initiatives. In this study, we aimed to elucidate the genetic basis of key agronomic and fruit-related traits using a reproducible ddRAD-seq protocol applied to a discovery panel of 90 peach accessions. Our customized workflow (available at https://github.

View Article and Find Full Text PDF

Comparison of gadobutrol and meglumine gadoterate for dynamic contrast-enhanced MRI of pituitary macroadenomas.

Sci Rep

July 2025

Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173-82, Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea.

In this study, we compared the performance of gadobutrol and meglumine gadoterate, two macrocyclic non-ionic and ionic contrast agents, for evaluating quantitative perfusion parameters of pituitary macroadenomas using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Patients with pituitary macroadenomas were prospectively enrolled and randomly assigned to be administered gadobutrol or meglumine gadoterate for MRI. Perfusion parameters of the pituitary macroadenoma, including Ktrans, Kep, Ve, and Vp, were measured using DCE-MRI.

View Article and Find Full Text PDF

Acid soaking with hydrochloric acid (HCl) is a common method used to prevent or break diapause in silkworm eggs and has been widely applied in production. However, its underlying mechanism remains to be explored. Few studies have reported on the metabolism of mono- or disaccharides, and the differential expression patterns of genes and proteins related to the phosphatidyl inositol 3-kinase (PI3K/)Akt signaling pathway across the stages of silkworm diapause eggs, non-diapause eggs, instant acid-soaked eggs, and red bean color acid-soaked (RBCAS) eggs.

View Article and Find Full Text PDF

NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress.

Sci Adv

July 2025

MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

WNK family kinases are regulated by osmotic stress and control ion homeostasis by activating SPAK and OXSR1 kinases. Using a proximity labeling approach, we found that osmotic stress promotes the association of WNK1 with the NRBP1 pseudokinase and TSC22D2/4 adaptor proteins, results that are confirmed by immunoprecipitation, mass spectrometry, and immunoblotting studies. NRBP1 pseudokinase is closely related to WNK isoforms and contains a RΦ-motif-binding conserved C-terminal (CCT) domain, like the CCT domains in WNKs, SPAK, and OXSR1.

View Article and Find Full Text PDF