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Nontuberculous mycobacteria (NTM) are a diverse group of environmental mycobacteria found ubiquitously in soil and water, causing infections that typically arise from environmental exposure rather than person-to-person transmission. This case report documents the first known detection of in our region, emphasizing the clinical challenges and diagnostic complexities associated with NTM infections. The case involves a 37-year-old male with a significant smoking history who presented with progressively worsening cough, significant weight loss, and bilateral cavitary lung lesions. Initial diagnostic efforts, including tests for tuberculosis and malignancy, were inconclusive. However, subsequent bronchoalveolar lavage confirmed the presence of , leading to a year-long treatment regimen. This report signifies a critical step in recognizing the burden of NTM infections in region, a region where comprehensive epidemiological data are lacking. The rising global incidence of NTM lung disease and its association with underlying lung conditions and immunocompromised states further underscore the importance of this case, particularly given the diagnostic overlap with more common conditions like tuberculosis. This case calls attention to the need for optimized local diagnostic criteria and the potential for NTM to be a causative agent of community-acquired pneumonia.
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http://dx.doi.org/10.1016/j.radcr.2024.10.151 | DOI Listing |
Int J Infect Dis
September 2025
SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa; Department of Microbiology and Biochemistry, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontei
Background: Mycobacterium simiae is a slow-growing environmental nontuberculous mycobacterium (NTM), commonly isolated from soil and water. M. simiae is not known to transmit zoonotically or via human-to-human contact; infection is presumed to occur through direct environmental exposure.
View Article and Find Full Text PDFMicrobiol Spectr
September 2025
Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Efficient DNA delivery is essential for genetic manipulation of mycobacteria and for dissecting their physiology, pathogenesis, and drug resistance. Although electroporation enables transformation efficiencies exceeding 10⁵ CFU per µg DNA in and , it remains highly inefficient in many nontuberculous mycobacteria (NTM), including . Here, we discovered that NTM such as exhibit exceptional tolerance to ultra-high electric field strengths and that hypertonic preconditioning partially protects cells from electroporation-induced damage.
View Article and Find Full Text PDFCase Rep Rheumatol
August 2025
Department of Rheumatology and Internal Medicine, Kamitsuga General Hospital, Kanuma, Tochigi, Japan.
Nontuberculous (NTM) infections affecting musculoskeletal structures are rare, particularly in patients with well-controlled rheumatoid arthritis (RA). This case is reported to highlight the potential risk of focal tenosynovitis due to following intra-articular glucocorticoid injection. A 79-year-old man with well-controlled RA developed tenosynovitis with bone destruction in the right index finger metacarpophalangeal joint following a single intra-articular injection of triamcinolone acetonide.
View Article and Find Full Text PDFInt J Infect Dis
September 2025
Goethe-University Frankfurt, University Hospital, Department of Medicine no. 2, Infectious Diseases. Electronic address:
Objectives: Disseminated nontuberculous mycobacterial disease (dNTMd) remains a rare but serious complication in people living with HIV (PLWH). This study aimed to assess whether dNTMd independently contributes to delayed CD4-cell recovery following antiretroviral therapy (ART) initiation.
Methods: This retrospective 1:3 single center case-control study analyzed patient data from 2004 to 2023.
IJID Reg
September 2025
Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
Objectives: Nontuberculous mycobacteria (NTM) are an increasing cause of extrapulmonary infections affecting skin and soft tissue. This study aimed to determine the involvement of NTM in persistent surgical site infections (SSIs) in Bangladesh.
Methods: Specimens of SSIs (wound swab, pus, sinus discharge) were collected from patients who attended a tertiary care hospital during a 6-month period in 2024.