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http://dx.doi.org/10.2215/CJN.0000000588 | DOI Listing |
Circ Cardiovasc Interv
September 2025
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy (F.T., G.A., M.G., K.S., D.D., G.S., M.C.).
Mitral regurgitation is the most common valve disease worldwide. Despite its wide success in inoperable or high-risk surgical patients, transcatheter edge-to-edge repair remains limited by some anatomic features and the not negligible rate of significant residual regurgitation. Transcatheter mitral valve replacement has emerged as a viable alternative that promises to overcome these issues, but its development has been progressing slowly.
View Article and Find Full Text PDFBlood Cell Ther
August 2025
Department of Clinical Hematology and Medical Oncology, Postgraduate Institute Of Medical Education And Research (PGIMER), Chandigarh, India.
Background: Bone marrow (BM) Measurable Residual Disease (MRD) assessments underestimate disease burden in multiple myeloma, as focal lesions can exist outside the marrow. Functional imaging, like positron emission tomography-computed tomography (PET-CT), offers valuable insights into residual disease beyond the marrow. Combining marrow flow cytometry (FCM) with PET-CT for a composite MRD (cMRD) assessment before and after autologous stem cell transplant (ASCT) is expected to provide prognostic information, particularly in settings where patients receive extended duration of anti-myeloma therapy prior to ASCT.
View Article and Find Full Text PDFCureus
August 2025
Department of Rheumatology and Bone Diseases, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, CHN.
Background: There is growing evidence that Sjögren's syndrome (SS) and atherosclerosis (AS) might share underlying immunological and inflammatory processes. Observational data have pointed toward a potential association between SS and a heightened likelihood of developing AS, though the causal direction and specific dynamics of this relationship have not been clearly verified. This Mendelian randomization (MR) investigation opts to investigate potential bidirectional causality between SS and three types of AS: coronary, cerebral, and peripheral.
View Article and Find Full Text PDFCureus
August 2025
Department of Neurosurgery, The University of Osaka Graduate School of Medicine, Suita, JPN.
Fungal cerebral aneurysms, particularly those resulting from direct invasion by fungal sinusitis, are rare and often fatal when involving the cavernous segment of the internal carotid artery (ICA). We present a case of a ruptured fungal ICA aneurysm caused by sinusitis, successfully treated with parent artery occlusion (PAO). In this case, an 80-year-old woman presented with right ptosis, facial pain, and cranial nerve III, IV, and VI palsies.
View Article and Find Full Text PDFCatheter Cardiovasc Interv
September 2025
Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: Patent foramen ovale (PFO) has been identified as a potential risk factor for cryptogenic stroke (CS). Although transesophageal echocardiography (TEE) is considered the gold standard for PFO detection, false-negative results remain a clinical concern, particularly in CS patients with high suspicion of PFO-related etiology.
Aims: To evaluate the clinical utility of transcatheter PFO exploration (TPFOE) in CS patients with negative TEE findings but high suspicion of PFO-related etiology.