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Leveraging publicly available data about schools' absenteeism from the New Jersey Department of Education, the present study examined how neighborhood-level resource deprivation and violent crime related to chronic absenteeism in Passaic County's elementary, middle, and high schools. Results highlighted geographic disparities in Passaic County, New Jersey, whereby predominantly racial/ethnic, under-resourced, communities of color have significantly greater levels of resource deprivation and threat. Additionally, greater neighborhood-level resource deprivation and neighborhood violent crime were associated with higher rates and trajectories of absenteeism across three academic school years. These findings highlight the importance of considering neighborhood context in absenteeism prevention programs.
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http://dx.doi.org/10.1177/00420859221125704 | DOI Listing |
Health Soc Care Deliv Res
September 2025
Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Background: Remote services (in which the patient and staff member are not physically colocated) and digital services (in which a patient encounter is digitally mediated in some way) were introduced extensively when the COVID-19 pandemic began in 2020. We undertook a longitudinal qualitative study of the introduction, embedding, evolution and abandonment of remote and digital innovations in United Kingdom general practice. This synoptic paper summarises study design, methods, key findings, outputs and impacts to date.
View Article and Find Full Text PDFNeuropharmacology
September 2025
College of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, China. Electronic address:
Aim Of The Study: This study aimed to investigate the protective effects of Geniposide (GEN) against cerebral ischemia-reperfusion injury by targeting the cGAS-STING pathway and modulating autophagy in neuronal cells.
Materials And Methods: In vivo middle cerebral artery occlusion/reperfusion (MCAO/R) model and an in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model to mimic the pathology of cerebral ischemic stroke in humans. Behavioral tests, tissue staining to assess neurological deficits and tissue damage in mice.
ESMO Open
September 2025
Aminex Therapeutics, Inc., Kenmore, USA. Electronic address:
Background: Dysregulation of polyamine synthesis has been observed in various cancer cell types. A novel approach to depriving cancer cells of polyamines involves the use of difluoromethylornithine (DFMO) to block polyamine biosynthesis in combination with AMXT 1501, a potent inhibitor of polyamine transport. Preclinical mouse tumor models showed that the combination of AMXT 1501 plus DFMO had strong antitumor activity, together with evidence of a stimulated immune response against tumors.
View Article and Find Full Text PDFGynecol Oncol
September 2025
University of Chicago, Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, Chicago, IL 60637, USA; University of Chicago, Department of Medicine, Section of Hematology/Oncology, Chicago, IL 60637, USA.
Objective: To identify associations between race, neighborhood disadvantage, and outcomes in women with stage I-III endometrioid endometrial cancer (EEC) treated at a tertiary referral center.
Methods: This retrospective tumor registry study included patients with stage I-III EEC between 1/2006 and 12/2022. Progression-free (PFS) and overall survival (OS) were analyzed by race and neighborhood disadvantage, stratified by Area Deprivation Index (ADI; national quartile).
J Cyst Fibros
September 2025
Cystic Fibrosis Foundation, Bethesda, MD, USA.
Introduction: Providing care to under-resourced patients places additional burdens on CF care teams, therefore it is important to identify programs that serve disproportionately disadvantaged populations.
Methods: Using the U.S.