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Department of Medicine, Faculty of Medicine, University Health Center (CHU) of Quebec Research Center, Laval University, QC, Canada.
Article Synopsis
- * By analyzing blood samples from 118 kidney recipients over a median follow-up of 6.3 years, researchers developed a risk score based on age and immune cell responses, categorizing patients into low, intermediate, and high-risk groups for OIS.
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Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Isohemagglutinin assays employing red blood cells (RBCs) are the most common assays used to measure antibody titer in ABO-incompatible kidney transplantation (ABOi KTx). However, ABO antigens expressed on RBCs are not identical to those of kidney and antibody titers do not always correlate with clinical outcome. We previously reported that CD31 was the main protein linked to ABO antigens on kidney endothelial cells (KECs), which was different from those on RBCs.
View Article and Find Full Text PDFA Sequential Two-Step Cell-Based Assay Predicts Immunosuppression-Related Adverse Events.
J Immunol
December 2020
Transplantation Unit, Renal Division, Department of Medicine, University Health Center of Quebec, Faculty of Medicine, Laval University, Quebec City, Quebec G1R 2J6, Canada; and
Immunosuppressants are associated with serious and often life-threatening adverse effects. To optimize immunotherapy, a tool that measures the immune reserve is necessary. We validated that a cell-based assay that measures TNF-α production by CD1416 intermediate monocytes following stimulation with EBV peptides has high sensitivity for the detection of over-immunosuppression (OIS) events.
View Article and Find Full Text PDFRecent advances in precision medicine for individualized immunosuppression.
Curr Opin Organ Transplant
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Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
Purpose Of Review: The current tools to proactively guide and individualize immunosuppression in solid organ transplantation are limited. Despite continued improvements in posttransplant outcomes, the adverse effects of over-immunosuppression or under-immunosuppression are common. The present review is intended to highlight recent advances in individualized immunosuppression.
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