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Pediatrics is an ever-evolving field, and clinicians focused on clinical care, including pediatric hospital medicine providers, are in an ideal position to develop research projects that advance evidence-based practice. However, clinical providers get pulled away from their research to deliver high-quality education and care at the bedside to children and families. The challenges of balancing these important goals are ones most faculty will face their entire career. This is most difficult for faculty taking on their first project, as they have yet to refine their research skills, learn their various institutional resources, and build a research team. The purpose of our manuscript is to offer 10 reflections to consider when developing your first research project. We intentionally focused on concepts we felt were highly relevant to first research project experiences. Our goal is to motivate talented clinicians and encourage the development of a solid project foundation to avoid the various pitfalls we have experienced.
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http://dx.doi.org/10.1542/hpeds.2023-007702 | DOI Listing |
Anaesthesiologie
September 2025
Klinik für Anästhesiologie, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität, Moorenstr. 5, 40225, Düsseldorf, Deutschland.
Sodium-glucose Cotransporter 2 (SGLT-2) inhibitors are oral antidiabetic drugs that were developed for the treatment of patients with diabetes mellitus and are now also approved for treating chronic heart failure and chronic kidney disease. By inhibiting SGLT‑2 in the proximal renal tubule, urinary excretion of glucose is increased. Large randomized trials have demonstrated improved glycemic control, reduced cardiovascular events and lower mortality but also an increased risk of urogenital infections and dehydration.
View Article and Find Full Text PDFCuad Bioet
September 2025
Universidad de A Coruña. Facultad de Derecho, Campus de Elviña, s/n, 15071, A Coruña. 981 167000 ext. 1640
The implications of the use of artificial intelligence (AI) in many areas of human existence compels us to reflect on its ethical relevance. This paper addresses the signification of its use in healthcare for patient informed consent. To this end, it first proposes an understanding of AI, as well as the basis for informed consent.
View Article and Find Full Text PDFEur J Trauma Emerg Surg
September 2025
French Military Medical Service Academy - École du Val-de-Grâce, Paris, France.
Background: Delivering intensive care in conflict zones and other resource-limited settings presents unique clinical, logistical, and ethical challenges. These contexts, characterized by disrupted infrastructure, limited personnel, and prolonged field care, require adapted strategies to ensure critical care delivery under resource-limited settings.
Objective: This scoping review aims to identify and characterize medical innovations developed or implemented in recent conflicts that may be relevant and transposable to intensive care units operating in other resource-limited settings.
Rheumatol Int
September 2025
Clinical Department of Rheumatology, Immunology and Internal Medicine, University Hospital in Kraków, Jakubowskiego 2, Kraków, 30-688, Poland.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by complex disturbances in both innate and adaptive immune responses, often leading to multi-organ involvement. One of the key features of SLE pathogenesis is endothelial dysfunction, which contributes to immune cell infiltration and vascular inflammation. In this context, adhesion molecules such as platelet endothelial cell adhesion molecule-1 (PECAM-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) may reflect the degree of endothelial activation.
View Article and Find Full Text PDFWorld J Urol
September 2025
Department of Urology, Hospital Clínico San Borja Arriarán, Santiago, Chile.
Purpose: Percutaneous nephrolithotomy (PCNL) is a common technique in the surgical management of renal lithiasis, but it also represents a significant workload for surgeons. Factors such as the patient's position and the type of lithotripter used influence the physical and mental load on the surgeon. The study aimed to identify stressors related to PCNL by comparing the physical and mental workload experienced by urologists during PCNL under different patient positions and using two lithotripters.
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