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http://dx.doi.org/10.1002/ajh.27541 | DOI Listing |
J Nucl Med
September 2025
Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland;
Noninvasive monitoring of immune responses is important for increasing the efficacy of cancer immunotherapy. Although several approaches exist, few methods directly report on T-cell activation. We aimed to develop a novel PET probe targeting C-X-C motif chemokine ligand 9 (CXCL9), a chemokine specifically induced by interferon gamma (IFN-γ), a cytokine that is produced by activated T cells and group 1 innate lymphoid cells.
View Article and Find Full Text PDFClin Exp Immunol
January 2025
Immunogenomics and Inflammation Unit, Hôpital Edouard Herriot, Hospices Civils de Lyon, France.
Introduction: Stromal-immune cell interactions promote pro-inflammatory cytokine secretion such as IL-17. IL-17 is involved in several chronic inflammatory diseases, affecting joints and skin. Podoplanin has been already identified as partially involved in high IL-17 secretion resulting from these cell interactions.
View Article and Find Full Text PDFCytotherapy
June 2025
Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; Transplantation Research Center, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:
Background Aims: This study evaluated the safety and efficacy of allogenic human bone marrow-derived mesenchymal stem cell (hBM-MSC) therapy in kidney transplant recipients (KTR) with chronic active antibody-mediated rejection (cABMR).
Methods: Seven cABMR patients received four infusions of hBM-MSC (1 × 10⁶ cells/kg), one every other week. The primary outcome was clinical safety, focusing on short-term adverse events.
Oncotarget
July 2025
Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
T play a deleterious role in the tumor microenvironment by suppressing anti-tumor effector T cells. Deletion of T can result in an enhanced anti-tumor response. It has been difficult to identify a cell surface antigen that is uniquely expressed on T which can be targeted by a deleting mAb.
View Article and Find Full Text PDFSci Rep
July 2025
Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London, SE1 1UL, UK.
IgD is the least well characterized of mammalian antibody isotypes and its biology remains poorly understood. Nanobodies are a useful and versatile tool for research and diagnostics, including for protein purification, capture and detection applications. Here we report the characterization of four anti-human IgD nanobodies, specific to the Fc region of IgD.
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