Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.molcel.2024.11.036 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preventable Hospitalizations and Kidney Care.
Clin J Am Soc Nephrol
September 2025
Department of Medicine, Section of Nephrology, Yale School of Medicine, New Haven, CT.
Among individuals with kidney disease hospitalization rates are up to 38% higher than the general population, increase proportionally with each stage of chronic kidney disease (CKD) and significantly contribute to over $130 billion in annual care costs in the United States (U.S.).
View Article and Find Full Text PDFMulti-Level Oncological Management of a Rare, Combined Mediastinal Tumor: A Case Report.
Curr Oncol
July 2025
Thoracic Surgery Department, "Theageneio" Cancer Hospital, 54639 Thessaloniki, Greece.
Malignant mediastinal tumors are a group representing some of the most demanding oncological challenges for early, multi-level, and successful management. The timely identification of any suspicious clinical symptomatology is urgent in achieving an accurate, staged histological diagnosis, in order to follow up with an equally detailed medical therapeutic plan (interventional or not) and determine the principal goals regarding efficient overall treatment in these patients. We report a case of a 24-year-old male patient with an incident-free prior medical history.
View Article and Find Full Text PDFTREM2 and Pain Development: An Old Molecule, a New Target.
J Neurochem
August 2025
Department of Neurology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
The essence of pain involves a multi-system interaction encompassing sensation, emotion, and cognition, with multi-level regulatory mechanisms such as peripheral sensitization, central plasticity, neuroimmune signal crosstalk, and glial cell activation playing critical roles. Among these mechanisms, microglia, as the primary immune effector cells in the central nervous system, contribute significantly to chronic pain by releasing pro-inflammatory factors and modulating synaptic remodeling. Nevertheless, significant gaps remain in our current understanding, including the molecular switch governing the transition from acute to chronic pain, the precise mechanisms regulating microglial phenotypic conversion, and the biological basis of endogenous pain resolution pathways.
View Article and Find Full Text PDFSpatial optimization of hierarchical healthcare facilities driven by multi-source data: a case study of Shenyang, China.
Front Public Health
August 2025
College of Architecture and Urban Planning, Shenyang Jianzhu University, Shenyang, China.
Amid rapid urbanization and accelerated population aging, spatial inequality in the distribution of healthcare facilities has become a pressing challenge in Shenyang. The dual problem of overconcentration of high-level medical resources in the urban core and insufficient primary care provision in peripheral areas highlights systemic imbalances in healthcare equity and efficiency. Grounded in the concept of spatial equity, this study integrates multi-source data-including population statistics, facility locations, and transportation networks-using advanced spatial analysis and big data fusion techniques.
View Article and Find Full Text PDF