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Platelet-rich plasma (PRP) is gaining popularity across various medical fields, including orthopedics, for its potential in tissue regeneration and wound healing. As intra-articular treatments evolve, PRP has emerged as a promising option for managing knee osteoarthritis, meniscus, and ligament injuries. This review aims to provide an update on the current applications of PRP in treating knee osteoarthritis and its clinical implications in orthopedic and sports medicine. We reviewed 180 eligible studies, and our findings suggest that PRP injections significantly improve knee joint function compared to alternative treatments. The use of PRP across various medical fields has been growing in popularity recently. PRP is a biological product derived from the plasma portion of a patient's own blood, containing a higher concentration of platelets than normal. Its potential for tissue regeneration and wound healing has drawn significant attention from orthopedic surgeons, especially as intra-articular treatment options continue to evolve. The benefits of PRP in treating various osteoarticular conditions have sparked considerable interest within the orthopedic community, particularly for managing knee osteoarthritis, meniscus tears, and ligament injuries. This review aims to provide an updated overview of the current applications of PRP in the treatment of knee osteoarthritis and to offer clinical insights into its use in orthopedic and sports medicine practices. We reviewed 180 relevant titles and abstracts that met the inclusion criteria. Compared to other treatment options, PRP injections significantly enhance knee joint function.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599444 | PMC |
http://dx.doi.org/10.1155/2024/6551525 | DOI Listing |
Clin Exp Immunol
September 2025
Orthopedic Center, Sunshine Union Hospital, High-tech Zone, Weifang City, Shandong Province, China.
Introduction: We attempted to perform a comprehensive bioinformatics analyses on osteoarthritis (OA) based on the NKT-related genes and explore the clinical related critical genes.
Methods: Differentially expressed genes (DEGs) and NKT-related genes from WGCNA were obtained using the dataset GSE114007, followed by intersection analysis to obtain NKT-related DEGs. Lasso regression, support vector machine and random forest were performed to screen feature genes, followed by verification with ROC curve, and nomogram model.
Orthop Rev (Pavia)
September 2025
Introduction/background: Complex articular fractures around the knee in the elderly patient present an ongoing challenge regarding optimal treatment. While extensive research has evaluated immediate arthroplasty following fracture of the proximal femur, distal femur, proximal humerus, and elbow, relatively little focus has been given to immediate arthroplasty following complex tibia plateau fractures.
Methods: As seen with many other fractures, arthroplasty can shorten recovery and hospital stay and allow early weight-bearing with improved mobility while minimizing complications and possible future conversion arthroplasty cost.
Stem Cells Int
August 2025
R&D Center, Wuhan Hamilton Biotechnology Co. Ltd, Wuhan, Hubei, China.
Osteoarthritis (OA) is the leading joint disease that causes joint pain and disability. Despite increasing progress regarding the therapeutic potential of human umbilical cord mesenchymal stem cells (UC-MSCs) for OA, effective strategies for the treatment of OA using UC-MSCs have not yet been developed in clinical practice. Our present study has proven that the early stage in OA rats is the main development stage of nod-like receptor heat protein domain protein 3 (NLRP3)-mediated synovial inflammation.
View Article and Find Full Text PDFJ Exp Orthop
July 2025
Department of Molecular Medicine and Surgery, Section of Sports Medicine Karolinska Institutet Stockholm Sweden.
Purpose: To assess the functional and subjective outcomes of combined anterior cruciate ligament reconstruction (ACLR) and lateral meniscal root tear (LMRT) repair. Additionally, to compare the use of an independent tunnel for LMRT repair with the ACL bone tunnel technique and to assess the failure rates of LMRT repair to isolated ACLR.
Methods: Patients who underwent primary ACLR and concomitant LMRT repair from May 2017 to May 2022 at Capio Artro Clinic, Stockholm, Sweden, were retrospectively identified and matched 1:3 (age, sex and graft type) with patients who underwent isolated ACLR during the same period.
J Exp Orthop
July 2025
Department of Orthopaedic Surgery Hôpital Pierre Paul Riquet, CHU de Toulouse Toulouse France.
Purpose: The aim of this study was to compare implant survival, clinical outcomes and radiographic alignment between navigated and non-navigated total knee arthroplasty (TKA) performed with a single implant system.
Methods: A retrospective multicenter analysis of prospectively collected data from 6078 TKAs performed for primary osteoarthritis using a single implant system was performed. Procedures were divided into two groups: navigated ( = 3602) and non-navigated ( = 2476).