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This study aimed to investigate the effects of inspiratory muscle training (IMT) on inspiratory muscle strength, dyspnea, and quality of life (QOL) in COPD patients. A comprehensive search was undertaken on the Web of Science, Scopus, Embase, Cochrane, and PubMed databases, encompassing data published up to 31 March 2024. A meta-analysis was subsequently conducted to quantify the standardized mean difference (SMD) and 95% confidence interval (CI) for the effects of IMT in COPD patients. Sixteen studies met the inclusion criteria. IMT significantly improved inspiratory muscle strength (SMD, 0.86, < 0.00001), dyspnea (SMD = -0.50, < 0.00001), and QOL (SMD = 0.48, = 0.0006). Subgroup analysis showed that <60% maximal inspiratory muscle pressure (PImax) IMT (inspiratory muscle strength, SMD = 1.22, = 0.005; dyspnea, SMD = -0.92, < 0.0001), IMT conducted for ≤20 min (inspiratory muscle strength, SMD = 0.97, = 0.008; dyspnea, SMD = -0.63, = 0.007; QOL, SMD = 1.66, = 0.007), and IMT conducted >3 times per week (inspiratory muscle strength, SMD = 1.06, < 0.00001; dyspnea, SMD = -0.54, < 0.00001; QOL, SMD = 0.48, = 0.0009) had greater effects. This meta-analysis provides clinicians with evidence supporting the recommendation that COPD patients engage in IMT at <60% PImax for more than 3 times per week, with each session lasting no more than 20 min, to improve inspiratory muscle strength, dyspnea, and QOL.
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http://dx.doi.org/10.3390/life14111470 | DOI Listing |
Ann Afr Med
September 2025
Department of Pediatrics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Background And Aims: Hypothyroid patients often complain of shortness of breath, fatigue, and exercise intolerance. Both inspiratory and expiratory muscles' weakness is present, and the impairment of pulmonary function may be initiated at the subclinical stage of hypothyroidism. Hence, this study aimed to assess the pulmonary function tests (PFTs) in hypothyroid patients.
View Article and Find Full Text PDFNeuroimage
September 2025
UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, INSERM, Sorbonne Université, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Département R3S, Paris, France. Electronic address:
Background: Neural respiratory drive (NRD) is a clinically relevant biomarker in patients with chronic obstructive pulmonary disease (COPD). However, its analysis is challenging due to several technical considerations, including the need to obtain a stable recording over a short time period. However, a short recording duration may be inadequate to comprehensively record clinically relevant information, particularly during sleep, because NRD varies across sleep stages and over time.
View Article and Find Full Text PDFDisabil Rehabil
September 2025
Research Center for Active Living and Wellbeing, Bragança, Portugal.
Purpose: To clarify the effect of inspiratory muscle training on inspiratory muscle strength, lung function, and functional capacity in hemodialysis patients.
Methods: Randomized controlled trials evaluating inspiratory muscle strength, lung function, and functional capacity in hemodialysis patients were searched. The search was conducted in Medline, Web of Science, and Scopus between August and December 2024.
Anal Cell Pathol (Amst)
September 2025
Department of Anesthesiology, The Second Affiliated Hospital of Shandong First Medical University, Shandong, Jinan, China.
The purpose of this study was to investigate the impact of sevoflurane (SEV) on cardiomyocyte (CM) pyroptosis following myocardial ischemia (MI). Reverse validation was performed by pharmacologically activating NLRP3 with monosodium urate (MSU) to confirm that SEV's cardioprotective effects were specifically mediated through the NLRP3 inflammasome pathway. Sprague Dawley rats were randomly assigned to sham (sham), model (conventional anesthesia + MI-reperfusion [MIR] injury modeling), SEV (SEV inhalation anesthesia + MIR injury modeling), and SEV + NLRP3 (SEV inhalation anesthesia + MIR injury modeling + NLRP3) groups.
View Article and Find Full Text PDFSupport Care Cancer
September 2025
CEU Fernando III, CEU Universities, 41930, Bormujos, Seville, Spain.
Purpose: Given the effects of inspiratory muscle training (IMT) on exercise tolerance of Breast Cancer survivor (BCS) and since IMT load is adjusted based on Maximal Inspiratory Pressure (MIP), the aim of this study was to evaluate MIP of BCS, compare it with the obtained from predictive equations for healthy women, and study the possible effects of physical activity level on it.
Methods: MIP was obtained from 50 BSC and compared with the theoretical values of MIP estimated through predictive equations of Black & Hyatt, and Hautmann. BCS were categorized in 25 active and 25 sedentary according to HUNT1-PAQ questionnaire.