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Spiral, one of the most well-known functional patterns in nature that can be observed in structures such as the proboscis of lepidoptera and snail shells or as vortices forming in flowing fluids, has long served as a source of inspiration for humans in the creation of numerous spiral-based designs. Double-spiral is a design derived from spirals, which has been previously presented and utilized as a compliant joint. Advantageous properties of double-spirals, such as easily adjustable design, multiple degrees of freedom, reversible extensibility, and tunable deformability make them promising candidates for the development of mechanically intelligent structures that exhibit unique behavior and reach desired functions, such as soft grippers, continuum manipulators, energy-dissipative structures, and foldable metamaterials. In this article, we first develop the Double-Spiral Design software to facilitate the design and modeling of double-spirals. We then design and manufacture five different spiral-based structures using three-dimensional (3D) printing, including (1) a freeform passive gripper, (2) a highly extensible enveloping gripper, (3) a mechanical interlocking structure, (4) an adaptive energy-dissipative structure, and (5) a compliant planar joint. Through practical experimentation, we test the functionality of the developed structures and showcase the potential of double-spirals for being used in various technical applications. This study represents a significant step towards a better understanding of double-spirals and demonstrates their broad but unexplored potential in engineering design.
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http://dx.doi.org/10.1038/s41598-024-79630-6 | DOI Listing |
J Phys Chem Lett
September 2025
Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, Oregon 97331, United States.
Carbon dots (CDs) represent a new class of nontoxic and sustainable nanomaterials with increasing applications. Among them, bright and large Stokes-shift CDs are highly desirable for display and imaging, yet the emission mechanisms remain unclear. We obtained structural signatures for the recently engineered green and red CDs by ground-state femtosecond stimulated Raman spectroscopy (FSRS), then synthesized orange CDs with similar size but much higher nitrogen dopants than red CDs.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Department of Chemical Engineering, National Taiwan University, Taipei 106319, Taiwan.
To address the increasingly limited water availability, using metal-organic frameworks (MOFs) to capture atmospheric water vapor as usable resources has emerged as a promising strategy. The adsorption characteristics of MOFs as well as their step pressure (i.e.
View Article and Find Full Text PDFJ Phys Chem A
September 2025
Department of Chemistry, Tsinghua University, Beijing 100084, China.
A series of Cu-based single-atom catalysts (SACs) with asymmetric coordination were designed to accelerate lithium-sulfur (Li-S) chemistry. The electronegativity contrast from the dopant induces a localized electronic asymmetry that amplifies Jahn-Teller distortion at the Cu center. This distortion profoundly modulates the Cu 3d electronic structure and its interaction with Li-S intermediates.
View Article and Find Full Text PDFMol Divers
September 2025
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, Xinjiang, China.
Aurora kinases are a group of serine/threonine kinases essential for cell mitosis, comprising Aurora A, B, and C. However, the Aurora B is overexpressed in multiple tumors and the aurone has been proved to exhibit potent inhibitory activity against Aurora B kinase by our group. The indolinone was considered as an aurone scaffold hopping analog, and the indolinone-based Aurora B inhibitor library (3577 molecules) was constructed by FBDD strategy.
View Article and Find Full Text PDFBiomater Sci
September 2025
Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, The Tianjin Key Laboratory of Biomaterials, Institute of Biomedical Engineering, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin, 300192, China.
Various cancer therapeutic strategies have been designed for targeting tumor-associated macrophages (TAMs), but TAM reprogramming-based monotherapy is often clinically hindered, likely due to the lack of a coordinated platform to initiate T cell-mediated immunity. Herein, we fabricated reactive oxygen species (ROS)-responsive human serum albumin (HSA)-based nanoparticles (PEG/IL12-IA NPs) consisting of indocyanine green (ICG), arginine (Arg), and interleukin 12 (IL12). Upon laser irradiation, the nanoparticles were found to be able to dissociate, thus facilitating the release of IL12.
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