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This quality improvement initiative aimed to increase first dose of COVID-19 vaccinations during pediatric/adolescent clinic visits. Four plan-do-study-act cycles were performed with creation of eligibility lists and increasing health educator (HE) engagement. Statistical process control analysis assessed vaccine receipt over time. Logistic regression modeling evaluated odds of receipt. Among 6,740 visits, 52.2% of patients were eligible for first COVID-19 vaccine; 17.9% of eligible patients accepted it. First-vaccine improvements from 13.1% to 21.7% were not sustained. Odds of receipt increased in each cycle compared with baseline (1: Odds Ratio=1.99 [95% Confidence Interval 1.49-2.67], 2: OR=2.22 [1.58-3.14]), 3: OR=2.15 [1.51-3.05]), 4: OR=1.48 [1.11-1.96]), and with HE discussion versus no HE discussion (OR=1.64 [1.16-1.90]). First COVID-19 vaccine receipt increased with vaccine-eligible patient lists and HE-initiated discussions, although improvements diminished over time. Health educator versus no HE discussion led to improved vaccinations, supporting further quality improvement research on HE role to improve vaccine uptake.
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http://dx.doi.org/10.1353/hpu.2024.a943983 | DOI Listing |
AAPS PharmSciTech
September 2025
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
The chimpanzee adenovirus-vectored vaccine developed by the University of Oxford (ChAdOx1 nCoV-19) showed good stability when stored in refrigerator. However, the vaccine manufacturer prefers its transportation in frozen condition. Data regarding the stability of the vaccine after exposure to repeated freezing processes have not been explored yet.
View Article and Find Full Text PDFVaccine
September 2025
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Background: Among pregnant and postpartum women, decision-making for receiving the COVID-19 vaccine is influenced by vaccine safety concerns, misconceptions, shifting vaccine policies, and exclusion in the initial vaccine rollout. This caused confusion and vaccine hesitancy among many groups including pregnant and postpartum women.
Objective: The objective of this study was to understand the multilevel factors that influence vaccine decision-making among pregnant and postpartum women in Pakistan, which is crucial for improving vaccine demand among the vulnerable group-pregnant and postpartum women.
J Am Coll Cardiol
September 2025
Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region of China; Advanced Data Analytics for Medical Science Limited, Hong Kong Special Administrative Region of China
Background: There is no consensus for using statins for primary prevention of cardiovascular disease (CVD) and all-cause mortality in adults with type 1 diabetes mellitus (T1DM), because no randomized controlled trial has exclusively investigated statins in this population.
Objectives: In this study, the authors sought to evaluate the long-term risks and benefits of statins for primary prevention in adults with T1DM.
Methods: We performed a sequential target trial emulation comparing statin initiation vs noninitiation using UK primary care data from the IQVIA Medical Research Data database.
Vaccine
September 2025
Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Background: Covid-19 vaccines are updated to match circulating strains based on reasoning that better strain-matched immunogenicity should provide better protection. Randomized evidence with disease endpoints to support strain matching is lacking. We evaluated COVID-19 incidence among adults randomized to a second booster of Prototype or Omicron-based vaccines.
View Article and Find Full Text PDFVaccine
September 2025
Department of Epidemiology, Institute of Social Medicine, University of State of the Rio de Janeiro. 524 São Francisco Xavier St. Maracanã, Bloco E, 7th Floor, Rio de Janeiro - RJ, Cep 20550-013, Brazil. Electronic address:
Background: There is limited data on adult opinions toward school-based vaccination programs, which can supplement clinic-based strategies in the Brazilian public health system. Since 2016, vaccination rates among Brazilian children and adolescents have shown worrisome declines, remaining well below full coverage, including for more recently introduced COVID-19 vaccines. School vaccination programs are not commonly implemented or monitored in Brazil.
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