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In this paper, we present the demonstration of a cavity-dumped Kerr-lens mode-locked femtosecond oscillator based on an Yb:CALYO crystal for the first time. With the assistance of an SESAM, the Kerr-lens mode-locked Yb:CALYO laser delivered pulses with an average power of 2.8 W at a repetition rate of 61.3 MHz, corresponding to a pulse energy of 45.6 nJ. By employing a Pockels Cell consisting of dual β-BBO crystals and a thin film polarizer for cavity dumping, laser pulses of 280 nJ were achieved at both 1 MHz and 10 kHz repetition rates. The shortest pulse duration measured was 233 fs without external compression, resulting in a peak power of 1.06 MW.
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http://dx.doi.org/10.1364/OE.537391 | DOI Listing |
Lasers Med Sci
September 2025
Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Microbial contamination of absorbable collagen membranes used in guided bone regeneration (GBR) may compromise healing outcomes. This study aimed to investigate whether the minimum inhibitory concentration (MIC) of hydrogen peroxide (HO) can improve the antibacterial effect of indocyanine green (ICG)-mediated antimicrobial photodynamic therapy (PDT) on absorbable collagen membranes while reducing the need for high HO concentrations. A laboratory-based model was developed using Streptococcus sanguinis and Staphylococcus aureus.
View Article and Find Full Text PDFBiomater Sci
September 2025
Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, The Tianjin Key Laboratory of Biomaterials, Institute of Biomedical Engineering, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin, 300192, China.
Various cancer therapeutic strategies have been designed for targeting tumor-associated macrophages (TAMs), but TAM reprogramming-based monotherapy is often clinically hindered, likely due to the lack of a coordinated platform to initiate T cell-mediated immunity. Herein, we fabricated reactive oxygen species (ROS)-responsive human serum albumin (HSA)-based nanoparticles (PEG/IL12-IA NPs) consisting of indocyanine green (ICG), arginine (Arg), and interleukin 12 (IL12). Upon laser irradiation, the nanoparticles were found to be able to dissociate, thus facilitating the release of IL12.
View Article and Find Full Text PDFSupport Care Cancer
September 2025
Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Purpose: To compare the efficacy of intraoral (IOPBM) and extraoral photobiomodulation (EOPBM) protocols for the prevention and treatment of oral mucositis (OM) in patients with oral or oropharyngeal squamous cell carcinoma (SCC) to submitted radiotherapy (RT).
Methods: This randomized, blinded, multicenter clinical trial enrolled 58 patients with oral or oropharyngeal SCC, who were allocated into two groups matched by treatment type, clinical stage, and RT modality. Group I (IOPBM) received intraoral photobiomodulation (PBM) with a continuous InGaAlP diode laser (660 nm, 100 mW, 0.
Simul Healthc
September 2025
From the Pratt School of Engineering, Duke University, Durham, NC.
Introduction: Women who experience postpartum hemorrhage (PPH) after giving birth rapidly lose blood, which may lead to shock or death without immediate intervention. PPH most often results from uterine atony, when the uterus fails to contract after delivery. Worldwide, PPH causes 10 deaths hourly, with most deaths occurring in low-income settings.
View Article and Find Full Text PDFRev Sci Instrum
September 2025
National Centre for Physics (NCP), Islamabad, Pakistan.
Time-resolved data acquisition is crucial for compositional analysis using Laser-Induced Breakdown Spectroscopy (LIBS). It can be managed by adjusting the delay time and gate width of the spectrometer. This study describes the compositional analysis of molybdenum (Mo) ore utilizing charge coupled device (CCD) and intensified charge-coupled device (ICCD) based LIBS systems.
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