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http://dx.doi.org/10.3389/fpsyt.2024.1504429 | DOI Listing |
Cancer Lett
September 2025
Department of Cell, Development and Cancer Biology, Knight Cancer Institute, Oregon Health and Sciences University, Portland, OR, USA; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.
Gemcitabine, a ribonucleotide reductase (RNR) inhibitor, is active in pancreatic ductal carcinoma (PDAC) patients, but unfortunately has a limited impact on long term outcomes. Gemcitabine induces nucleotide deficiency, DNA damage including single stranded DNA (ssDNA) and replication stress (RS). DNA damage can activate cyclic GMP-AMP synthase (cGAS), leading to genome instability, micronucleus generation, and immune activation.
View Article and Find Full Text PDFEur Heart J Open
September 2025
Department of Cardiology, Centre Hospitalier Universitaire de Besançon, Besançon, France.
Int J Ment Health Nurs
October 2025
Faculty of Medicine and Health, University of New England, Tamworth, New South Wales, Australia.
JACC Clin Electrophysiol
August 2025
Electrophysiology Section, Division of Cardiology; University of Michigan, Ann Arbor, MI. Electronic address: