APAtizer: a tool for alternative polyadenylation analysis of RNA-Seq data.

Bioinformatics

Gene Regulation Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal.

Published: November 2024


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Article Abstract

Summary: APAtizer is a tool designed to analyze alternative polyadenylation events on RNA-sequencing data. The tool handles different file formats, including BAM, htseq, and DaPars bedGraph files. It provides a user-friendly interface that allows users to generate informative visualizations, including Volcano plots, heatmaps, and gene lists. These outputs allow the user to retrieve useful biological insights such as the occurrence of polyadenylation events when comparing two biological conditions. In addition, it can perform differential gene expression, gene ontology analysis, visualization of Venn diagram intersections, and correlation analysis.

Availability And Implementation: Source code and example case studies for APAtizer are available at https://github.com/GeneRegulationi3S/APAtizer/.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601165PMC
http://dx.doi.org/10.1093/bioinformatics/btae689DOI Listing

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APAtizer: a tool for alternative polyadenylation analysis of RNA-Seq data.

Bioinformatics

November 2024

Gene Regulation Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal.

Summary: APAtizer is a tool designed to analyze alternative polyadenylation events on RNA-sequencing data. The tool handles different file formats, including BAM, htseq, and DaPars bedGraph files. It provides a user-friendly interface that allows users to generate informative visualizations, including Volcano plots, heatmaps, and gene lists.

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